Genetics of sarcoidosis

Hereditary susceptibility to sarcoidosis is suggested by ethnic preponderance, familial clustering, and multigenerational involvement. The genetics of sarcoidosis cannot be adequately addressed in small samples of patients; a large-scale study with stratification for patient phenotypic differences i...

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Bibliographic Details
Published in:	Clinics in chest medicine Vol. 18; no. 4; p. 707
Main Authors:	Rybicki, B A, Maliarik, M J, Major, M, Popovich, Jr, J, Iannuzzi, M C
Format:	Journal Article
Language:	English
Published:	United States 01-12-1997
Subjects:	Female Genetic Linkage HLA Antigens - genetics Humans Male Sarcoidosis - genetics
Online Access:	Get more information
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Summary:	Hereditary susceptibility to sarcoidosis is suggested by ethnic preponderance, familial clustering, and multigenerational involvement. The genetics of sarcoidosis cannot be adequately addressed in small samples of patients; a large-scale study with stratification for patient phenotypic differences is necessary. A study that uses both genetic marker and environmental data would be able to control for and examine different causative mechanisms. Until such a well-designed, comprehensive study is carried out, we are left with interesting patterns of disease in families and uncertain allelic associations.
ISSN:	0272-5231
DOI:	10.1016/S0272-5231(05)70414-7