Stressor induced variations of intracranial self-stimulation from the mesocortex in several strains of mice

• Published in: Brain research Vol. 533; no. 2; p. 353
• Main Authors: Zacharko, R M, Gilmore, W, MacNeil, G, Kasian, M, Anisman, H
• Format: Journal Article
• Language: English
• Published: Netherlands 19-11-1990
• Subjects: Animals; Cerebral Cortex - physiology; Electric Stimulation; Electrodes, Implanted; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Self Stimulation - physiology; Species Specificity; Stress, Physiological - physiopathology
• ISSN: 0006-8993
• DOI: 10.1016/0006-8993(90)91363-L

Intracranial self-stimulation (ICSS) from the mesocortex was assessed in BALB/cByJ, C57BL/6J and DBA/2J mice immediately, 24 h and again 168 h following stressor application. Stressor exposure failed to influence ICSS performance in C57BL/6J mice, while self-stimulation performance was reduced among BALB/cByJ mice only in the immediate post-stressor interval. In contrast, DBA/2J mice exhibited reduced rates of responding for brain stimulation at each of the post-stressor intervals. The potential contribution of DA alterations to the strain-dependent variations of ICSS performance induced by uncontrollable footshock are discussed.