Insulin Resistance in Association with Thyroid Function, Psychoemotional State, and Cardiovascular Risk Factors

• Published in: International journal of environmental research and public health Vol. 18; no. 7; p. 3388
• Main Authors: Kazukauskiene, Nijole, Podlipskyte, Aurelija, Varoneckas, Giedrius, Mickuviene, Narseta
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25-03-2021; MDPI
• Subjects: Aged; Aged, 80 and over; Anxiety; Biochemical analysis; Blood Glucose; Blood pressure; Body mass index; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Clinical medicine; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - epidemiology; Electrocardiography; Emotions; Epidemiology; Fasting; Female; Glucose; Health risks; Heart Disease Risk Factors; Homeostasis; Hormones; Humans; Hypertension; Infrared analysis; Insulin; Insulin Resistance; Male; Marital status; Mental depression; Metabolic disorders; Metabolic syndrome; Middle Aged; Obesity; Quality of life; Questionnaires; Risk analysis; Risk Factors; Statistical analysis; Thyroid; Thyroid Gland; Weight control; Lithuania; coronary artery disease; psychoemotional; thyroid function; insulin resistance
• DOI: 10.3390/ijerph18073388
• EISSN: 1660-4601
• ISSN: 1660-4601; 1661-7827

Individuals with insulin resistance (IR) have a high risk of diabetes or metabolic syndrome, and they are more likely to have depression. Furthermore, IR by itself is a major cardiovascular risk factor in healthy persons. Thus, we aimed to investigate IR in association with thyroid function, psychoemotional state, and cardiovascular risk factors among 45-84-year-old citizens of Palanga.
A randomized epidemiological study was performed with 850 subjects. All participants were evaluated for sociodemographic, clinical, and cardiovascular risk factors and biochemical analysis. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR).
All study participants were stratified into groups without IR (HOMA-IR ≤ 2.7) and with IR (HOMA-IR > 2.7). The analysis of parameters between the two study groups showed some statistically significant relationships between IR and cardiovascular risk factors. The predictable accuracy was presented using receiver performance characteristic curves for HOMA-IR scores in women and men separately. If the HOMA-IR score is higher than 3.45, individuals are significantly more likely to have type 2 diabetes mellitus (T2DM).
An increase of fasting glucose and more frequent incidence of metabolic syndrome, diabetes, and cardiovascular diseases in subjects with IR are associated with the prevalence of cardiovascular risk factors. There was no significant association between thyroid function and HOMA-IR. HOMA-IR cut-offs could predict the presence of T2DM.