Uterine leiomyoma with massive lymphoid infiltrate in a patient with history of assisted in-vitro fertilization

• Published in: Türk patoloji dergisi Vol. 36; no. 3; pp. 251 - 255
• Main Authors: Prete, Monia Di, Collamarini, Matteo, Collamarini, Claudio, Sesti, Francesco, Mauriello, Alessandro, Palmieri, Giampiero
• Format: Journal Article
• Language: English
• Published: Ankara, Turkey Federation of Turkish Pathology Societies 01-09-2020
• Subjects: Case Report; in-vitro fertilization; leiomyoma; lymphoma; uterine
• ISSN: 1018-5615; 1309-5730
• DOI: 10.5146/tjpath.2019.01476

Uterine leiomyomas are the most common benign tumors of the gynecological tract. Massive lymphocytic infiltration has been reported rarely in uterine leiomyomas and it has been described as a pathogenetic correlation with gonadotropin-releasing hormone agonists. Uterine leiomyomas with massive lymphoid infiltration have to be differentiated from non-Hodgkin lymphomas. We report a case of a woman without a history of gonadotropin-releasing hormone agonist treatment, who presented with a uterine leiomyoma that increased in size after the procedure of assisted in-vitro fertilization, and associated with massive nodular lymphoid infiltrate simulating, morphologically, a non-Hodgkin lymphoma. Uterine leiomyoma with massive lymphocytic infiltration is a very rare entity, probably of reactive significance, which has to be differentiated from diseases that need a systemic therapeutic approach.