Neutrophil‐to‐lymphocyte ratio: Prognostic indicator for head and neck squamous cell carcinoma

• Published in: Head & neck Vol. 39; no. 4; pp. 662 - 667
• Main Authors: Rosculet, Nicholas, Zhou, Xian Chong, Ha, Patrick, Tang, Mei, Levine, Marshall A., Neuner, Geoffrey, Califano, Joseph
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-04-2017
• Subjects: Aged; Analysis of Variance; Biomarkers, Tumor - blood; Carcinoma, Squamous Cell - blood; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Cohort Studies; Combined Modality Therapy; Databases, Factual; Disease-Free Survival; Female; Head and Neck Neoplasms - blood; Head and Neck Neoplasms - mortality; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - therapy; head and neck squamous cell carcinoma; human papillomavirus (HPV); Humans; inflammatory markers; Logistic Models; Lymphocyte Count; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - therapy; Neutrophils - metabolism; neutrophil‐to‐lymphocyte ratio; Papillomaviridae; Prognosis; Proportional Hazards Models; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck; Survival Analysis; human papillomavirus (HPV); inflammatory markers; neutrophil-to-lymphocyte ratio; prognosis; head and neck squamous cell carcinoma
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.24658

Background
The neutrophil‐to‐lymphocyte ratio (NLR) has prognostic significance for many cancers, with higher values correlating with poor outcomes. The purpose of this study was to determine the prognostic significance of this inflammatory marker for patients with head and neck squamous cell carcinoma (HNSCC).
Methods
Univariate logistic regression and multivariate Cox regression analyses were performed on a retrospective cohort of 123 patients treated with primary chemoradiotherapy.
Results
The NLR is an indicator of both recurrence‐free and overall survival, but the NLR does not have independent prognostic significance when the favorable prognostic influence of human papillomavirus (HPV) status is incorporated into multivariate models.
Conclusion
The interaction between NLR and HPV status suggests that HPV status may be a determining factor in the favorable prognosis associated with a decreased NLR in HNSCC; these findings also suggest that HPV status may interact with the prognostic associations of indicators of systemic inflammation in HNSCC. © 2017 Wiley Periodicals, Inc. Head Neck 39: 662–667, 2017