Evidence That 'Brain-Specific' Fox-1, Fox-2, and nPTB Alternatively Spliced Isoforms Are Produced in the Lens

Purpose: Alternative RNA splicing is essential in development and more rapid physiological processes that include disease mechanisms. Studies over the last 20 years demonstrated that RNA binding protein families, which mediate the alternative splicing of a large percentage of genes in mammals, conta...

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Bibliographic Details
Published in:	Current eye research Vol. 36; no. 4; pp. 321 - 327
Main Authors:	Bitel, Claudine L., Nathan, Rachel, Wong, Patrick, Kuppasani, Sunil, Matsushita, Masafumi, Kanazawa, Hrioshi, Frederikse, Peter H.
Format:	Journal Article
Language:	English
Published:	England Informa Healthcare 01-04-2011 Taylor & Francis
Subjects:	Alternative Splicing Amino Acid Sequence Animals Base Sequence Brain - metabolism Exons - genetics Fluorescent Antibody Technique, Indirect Fox-1 Gene Expression Regulation - physiology Immunoblotting Kinesin - genetics Lens Lens, Crystalline - metabolism Mice Mice, Inbred C57BL Molecular Sequence Data Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Polypyrimidine tract binding proteins Polypyrimidine Tract-Binding Protein - genetics Polypyrimidine Tract-Binding Protein - metabolism Protein Isoforms - genetics Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA binding proteins RNA Splicing - genetics RNA Splicing Factors RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism
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