GUARD during ischemia against necrosis (GUARDIAN) trial in acute coronary syndromes

The plasma membrane sodium–hydrogen exchange system plays a major role in the pathophysiology of myocardial ischemia and reperfusion injury. The GUARD During Ischemia Against Necrosis (GUARDIAN) trial was undertaken to assess the potential clinical benefits of cariporide, a novel inhibitor of the so...

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Bibliographic Details
Published in:	The American journal of cardiology Vol. 83; no. 10; pp. 23 - 25
Main Author:	Erhardt, Leif R.W
Format:	Journal Article Conference Proceeding
Language:	English
Published:	New York, NY Elsevier Inc 20-05-1999 Elsevier Elsevier Limited
Subjects:	Adult Aged Angioplasty, Balloon, Coronary Anti-Arrhythmia Agents - adverse effects Anti-Arrhythmia Agents - therapeutic use Biological and medical sciences Cardiovascular disease Cardiovascular system Cause of Death Clinical trials Coronary Artery Bypass Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Drug therapy Female Guanidines - adverse effects Guanidines - therapeutic use Heart Humans Infusions, Intravenous Male Medical procedures Medical sciences Middle Aged Miscellaneous Myocardial Infarction - drug therapy Myocardial Reperfusion Injury - drug therapy Myocardium - pathology Necrosis Pharmacology. Drug treatments Prospective Studies Sodium-Hydrogen Exchangers - antagonists & inhibitors Sulfones - adverse effects Sulfones - therapeutic use Treatment Outcome Human Infarct Toxicity Acute Treatment efficiency Mortality Cardioprotective agent Cariporide Cardiovascular disease Myocardial disease Coronary heart disease Prevention Chemotherapy Treatment Myocardium
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