1-Methyl-4-phenylpyridinium ion (MPP+): identification of a metabolite of MPTP, a toxin selective to the substantia nigra

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a newly described neurotoxin which selectively destroys cells in the substantia nigra when administered systemically to primates. Because the substance creates a condition in humans which is virtually indistinguishable from Parkinson's dise...

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Bibliographic Details

Published in:	Neuroscience letters Vol. 48; no. 1; p. 87
Main Authors:	Langston, J W, Irwin, I, Langston, E B, Forno, L S
Format:	Journal Article
Language:	English
Published:	Ireland 13-07-1984
Subjects:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenylpyridinium Animals Biotransformation Brain - metabolism Chromatography, High Pressure Liquid Male Pyridines - metabolism Pyridines - toxicity Pyridinium Compounds - metabolism Saimiri Substantia Nigra - drug effects Substantia Nigra - metabolism
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