Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism

Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism

Foot shock stress selectively elevates dopamine metabolism in the medial frontal cortex but not nucleus accumbens or caudate nucleus. Pretreatment with a low dose of naloxone, an opiate antagonist, reversed the elevation in medial frontal cortex dopamine metabolism observed after foot shock. These d...

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Bibliographic Details
Published in:European journal of pharmacology Vol. 98; no. 3-4; p. 437
Main Authors: Miller, J D, Speciale, S G, McMillen, B A, German, D C
Format: Journal Article
Language:English
Published: Netherlands 02-03-1984
Subjects:
Animals
Depression, Chemical
Dopamine - metabolism
Electroshock
Frontal Lobe - metabolism
Male
Naloxone - pharmacology
Rats
Rats, Inbred Strains
Stress, Physiological - metabolism
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Summary:Foot shock stress selectively elevates dopamine metabolism in the medial frontal cortex but not nucleus accumbens or caudate nucleus. Pretreatment with a low dose of naloxone, an opiate antagonist, reversed the elevation in medial frontal cortex dopamine metabolism observed after foot shock. These data support the hypothesis that the stress-induced release of endogenous opioids cause an excitation of mesocortical dopamine neurons.
ISSN:0014-2999
DOI:10.1016/0014-2999(84)90295-4