Addition of Cyanoethyl Groups to Ring a of Triterpenoids

Addition of Cyanoethyl Groups to Ring a of Triterpenoids

The potential for cyanoethylation of ring A of triterpenoids and their A-seco derivatives prepared from allobetulone and methyl betulonate was investigated. Triterpenoids with a cyanoethyl moiety on C-1, C-2, and C-3 and derivatives with two cyanoethyl groups on ring A were synthesized. The inhibito...

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Bibliographic Details
Published in:Chemistry of natural compounds Vol. 54; no. 2; pp. 305 - 309
Main Authors: Galaiko, N. V., Tolmacheva, I. A., Igosheva, E. V., Savinova, O. V., Grishko, V. V.
Format: Journal Article
Language:English
Published: New York Springer US 01-03-2018
Springer
Springer Nature B.V
Subjects:
Cyanoethylation
Derivatives
Epidemiology
Medicine
Nitriles
Organic Chemistry
Pharmacy
Plant Sciences
Synthesis
Viruses
herpes simplex virus type 1
A-seco-triterpenoids
triterpenoids
cyanoethylation
acrylonitrile
betulin
antiviral activity
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Summary:The potential for cyanoethylation of ring A of triterpenoids and their A-seco derivatives prepared from allobetulone and methyl betulonate was investigated. Triterpenoids with a cyanoethyl moiety on C-1, C-2, and C-3 and derivatives with two cyanoethyl groups on ring A were synthesized. The inhibitory activity of the synthesized compounds for herpes simplex virus type 1 was studied in vitro.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-018-2329-8