Absorption of 3-nitropropanol and 3-nitropropionic acid from the digestive system of sheep

• Published in: Toxicology letters Vol. 23; no. 1; p. 1
• Main Authors: Pass, M A, Majak, W, Muir, A D, Yost, G S
• Format: Journal Article
• Language: English
• Published: Netherlands 01-01-1984
• Subjects: 1-Propanol - metabolism; Animals; Intestinal Absorption; Intestine, Small - metabolism; Nitrites - blood; Nitro Compounds; Propanols; Propionates - blood; Propionates - metabolism; Rumen - metabolism; Sheep - metabolism
• ISSN: 0378-4274
• DOI: 10.1016/0378-4274(84)90002-X

When 3-nitropropanol (NPOH) was injected into the rumen (30 mg/kg), abomasum (10 mg/kg) or small intestine (10 mg/kg) of sheep, it was rapidly absorbed and converted to 3-nitropropionic acid (NPA). The reticulo-rumen was the major site of absorption for the miserotoxin aglycone but the abomasum and the small intestine also had the capacity to absorb NPOH. When NPA was injected into different regions of the alimentary tract, the reticulo-rumen was also the major site of absorption. Absorption of NPA or NPOH from the small intestine was much more rapid than from the abomasum. Plasma levels of NPA and inorganic nitrite were higher after dosing with NPOH than with NPA indicating a more rapid rate of uptake of the aglycone.