delta-9-Tetrahydrocannabinol regulates gene expression of the growth factor pleiotrophin in the forebrain

delta-9-Tetrahydrocannabinol (THC) is a major psychoactive component of cannabis. We here studied, by quantitative in situ hybridization at the macroscopic level, the possible modulatory effects of acute THC (5 mg/kg/i.p.) on gene expression of the growth factor pleiotrophin (PTN) in the adult rat f...

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Bibliographic Details
Published in:	Neuroscience letters Vol. 175; no. 1-2; p. 25
Main Authors:	Mailleux, P, Preud'homme, X, Albala, N, Vanderwinden, J M, Vanderhaeghen, J J
Format:	Journal Article
Language:	English
Published:	Ireland 04-07-1994
Subjects:	Animals Carrier Proteins - biosynthesis Cytokines - biosynthesis Dronabinol - pharmacology Gene Expression Regulation - drug effects Male Nerve Growth Factors - biosynthesis Organ Specificity Prosencephalon - drug effects Prosencephalon - metabolism Rats Rats, Wistar RNA, Messenger - analysis RNA, Messenger - biosynthesis
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Summary:	delta-9-Tetrahydrocannabinol (THC) is a major psychoactive component of cannabis. We here studied, by quantitative in situ hybridization at the macroscopic level, the possible modulatory effects of acute THC (5 mg/kg/i.p.) on gene expression of the growth factor pleiotrophin (PTN) in the adult rat forebrain. We found, 30 min after a single injection of THC, a significant increase of PTN mRNA concentrations in the cingulate cortex (38%), fronto-parietal cortex (31%) and caudate-putamen (27%). In conclusion, this is the first report on THC regulation of growth factor gene expression in the brain.
ISSN:	0304-3940
DOI:	10.1016/0304-3940(94)91069-3