DNA Strand breaks in testicular cells from humans and rats following in vitro exposure to 1,2-dibromo-3-chloropropane (DBCP)

Preparations of testicular cells from human organ transplant donors and from Wistar rats were compared with respect to their composition of the different testicular cell types, their ability to metabolize 1,2-dibromo-3-chloropropane (DBCP), and their relative sensitivity to induction of DNA single s...

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Bibliographic Details
Published in:	Reproductive toxicology (Elmsford, N.Y.) Vol. 10; no. 1; pp. 51 - 59
Main Authors:	Bjørge, Christine, Wiger, Richard, Holme, Jørn A., Brunborg, Gunnar, Scholz, Tim, Dyeing, Erik, Søderlund, Erik J.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 1996 Elsevier
Subjects:	4-Nitroquinoline-1-oxide - toxicity 4-NQO Adult Aged Animals Binding Sites Biological and medical sciences Biotransformation Carcinogens - toxicity DBCP DNA Damage Electrophoresis Flow Cytometry Germ Cells - cytology Germ Cells - drug effects Germ Cells - radiation effects Germ Cells - ultrastructure human Humans In Vitro Techniques Insecticides - metabolism Insecticides - toxicity Male Medical sciences Microscopy, Electron Middle Aged Pesticides, fertilizers and other agrochemicals toxicology Propane - analogs & derivatives Propane - metabolism Propane - toxicity rat Rats Rats, Wistar testicular cells Testis - cytology Testis - drug effects Testis - metabolism Testis - radiation effects Testis - ultrastructure Toxicology x rays X-Rays - adverse effects 4-NQO rat DBCP DNA damage testicular cells x rays human Human Reproduction diseases Rat Toxicity Interspecific comparison Rodentia Pesticides Fumigant Germinal cell Metabolism Testicle In vitro Vertebrata Chromosome break Mammalia Animal DNA Male genital diseases
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