The relative effects of hypoxic hypoxia and carbon monoxide on brain function in rabbits

• Published in: Toxicology (Amsterdam) Vol. 75; no. 1; p. 71
• Main Authors: Ludbrook, G L, Helps, S C, Gorman, D F, Reilly, P L, North, J B, Grant, C
• Format: Journal Article
• Language: English
• Published: Ireland 01-10-1992
• Subjects: Animals; Brain - blood supply; Brain - drug effects; Brain - physiology; Carbon Monoxide - toxicity; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Dose-Response Relationship, Drug; Hypoxia - physiopathology; Male; Nitrogen - administration & dosage; Oxygen - metabolism; Rabbits
• ISSN: 0300-483X
• DOI: 10.1016/0300-483X(92)90127-Z

New Zealand white rabbits were exposed to control conditions (n = 11), or to either a progressive hypoxic hypoxia produced by dilution of oxygen (O2) with nitrogen (n = 10) or a 1% carbon monoxide (CO) admixture for 15 min (n = 11). Both exposures caused a significant increase in cerebral blood flow (CBF) of up to 300% such that O2 delivery to the brain was unchanged. In the hypoxia group, a cortical somatosensory evoked response (CSER) was unaffected until the arterial O2 tension was below 20 mmHg. At this time, the rabbits became hypotensive, O2 delivery to the brain decreased dramatically and the CSER could not be elicited. In contrast, despite the maintenance of O2 delivery to the brain during and after the CO exposure, the CSER voltages were halved during the exposure and only recovered to about 80% of baseline subsequently. We conclude that the primary toxicity of CO to the brain in rabbits is not due to a reduction in O2 delivery.