Prospective uses of recombinant Lactococcus lactis expressing both listeriolysin O and mutated internalin A from Listeria monocytogenes as a tool for DNA vaccination

In this study, Lactococcus lactis was engineered to express mutated internalin A on its surface and to secrete large amounts of listeriolysin O (LLO) in order to improve its potential as a vehicle for DNA vaccination. Western blotting experiments demonstrated that the bacterium expressed LLO in both...

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Bibliographic Details
Published in:	Genetics and molecular research Vol. 14; no. 4; pp. 18485 - 18493
Main Authors:	De Azevedo, M S P, Santos Rocha, C, Pereira, V B, De Oliveira Junior, A F, De Sousa, C S, Azevedo, V, LeBlanc, J G, Chatel, J M, Miyoshi, A
Format:	Journal Article
Language:	English
Published:	Brazil Ribeirão Preto foundation for Scientific Research (FUNPEC) 01-01-2015
Subjects:	Bacterial Proteins - genetics Bacterial Proteins - immunology Bacterial Toxins - genetics Bacterial Toxins - immunology Bacterial Vaccines Cell Membrane - metabolism Gene Expression Heat-Shock Proteins - genetics Heat-Shock Proteins - immunology Hemolysin Proteins - genetics Hemolysin Proteins - immunology Hemolysis Lactococcus lactis Lactococcus lactis - genetics Lactococcus lactis - metabolism Life Sciences Listeria monocytogenes Listeria monocytogenes - immunology Mutation Recombinant Proteins Vaccination listériolysine listeria monocytogènes Listeriolysin O Mutated internalin A lactococcus lactis internaline lactic acid bacteria bactérie lactique
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