Involvement of the "tethered-ligand" receptor in thrombin inhibition of platelet adenylate cyclase

Thrombin is thought to activate platelets through multiple signaling pathways. Recently a new thrombin receptor was identified (Vu et al., Cell 64:1057-1068, 1991) that recognizes alpha-thrombin's anion-binding exosite. Thrombin cleaves this receptor generating a new N-terminal ("tethered-...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 182; no. 3; p. 1296
Main Authors:	Seiler, S M, Michel, I M, Fenton, 2nd, J W
Format:	Journal Article
Language:	English
Published:	United States 14-02-1992
Subjects:	Adenylyl Cyclase Inhibitors Adenylyl Cyclases - blood Amino Acid Sequence Blood Platelets - drug effects Blood Platelets - enzymology Blood Platelets - physiology Cyclic AMP - blood Dose-Response Relationship, Drug Humans Iloprost - antagonists & inhibitors Iloprost - pharmacology In Vitro Techniques Kinetics Ligands Molecular Sequence Data Peptide Fragments - pharmacology Peptides - pharmacology Receptors, Cell Surface - drug effects Receptors, Cell Surface - physiology Receptors, Thrombin Thrombin - isolation & purification Thrombin - metabolism Thrombin - pharmacology
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