Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines

• Published in: Toxicology letters Vol. 72; no. 1-3; p. 53
• Main Authors: Perchermeier, M M, Kiefer, F, Wiebel, F J
• Format: Journal Article
• Language: English
• Published: Netherlands 01-06-1994
• Subjects: Animals; Biotransformation; Cell Line; Cricetinae; Cricetulus; Dinitrophenols - pharmacokinetics; Dinitrophenols - toxicity; Drug Evaluation, Preclinical - methods; Mice; Mutagens - pharmacokinetics; Mutagens - toxicity; Nitro Compounds - pharmacokinetics; Nitro Compounds - toxicity; Nitrobenzenes - pharmacokinetics; Nitrobenzenes - toxicity; Nitrophenols - pharmacokinetics; Nitrophenols - toxicity; Polycyclic Compounds - pharmacokinetics; Polycyclic Compounds - toxicity; Pyrenes - pharmacokinetics; Pyrenes - toxicity; Rats; Sensitivity and Specificity; Toluene - analogs & derivatives; Toluene - pharmacokinetics; Toluene - toxicity
• ISSN: 0378-4274
• DOI: 10.1016/0378-4274(94)90009-4

The cytotoxicity of polycyclic and monocyclic nitroarenes was tested in cell lines V79/NH, H4IIEC3/G-, 5L and BWI-J, which are distinguished by their specific expression of xenobiotic metabolizing enzymes. The results show that polycyclic nitroarenes differentially affect the test cell lines suggesting that some compounds, such as 1,3-dinitropyrene, are activated by cytochrome P4501A1, others, such as 1,6-dinitropyrene, by reductase(s) and acetyltransferase. No such cell specific responses were seen for 13 monocyclic nitroarenes tested. This group of chemicals apparently is activated by an enzyme(s) other than the polycyclic nitroarenes tested.