Progesterone antagonist (RU 486) for cervical dilation, labor induction, and delivery in monkeys: effectiveness in combination with oxytocin

A progesterone antagonist (RU 486), combined with oxytocin, was effective in achieving cervical dilation, labor induction, and early delivery in near-term monkeys. Effects of RU 486 included accelerated flow of colostrum and transiently enhanced weight gain in infants. No overt toxicity on fetuses,...

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Bibliographic Details
Published in:	American journal of obstetrics and gynecology Vol. 160; no. 1; p. 45
Main Authors:	Wolf, J P, Sinosich, M, Anderson, T L, Ulmann, A, Baulieu, E E, Hodgen, G D
Format:	Journal Article
Language:	English
Published:	United States 01-01-1989
Subjects:	Animals Cervix Uteri - drug effects Colostrum - immunology Colostrum - metabolism Drug Therapy, Combination Estrenes - pharmacology Estrenes - therapeutic use Female Immunoglobulins - analysis Labor, Induced - methods Lactation - drug effects Macaca fascicularis Mifepristone Oxytocin - pharmacology Oxytocin - therapeutic use Pregnancy Progesterone - antagonists & inhibitors Weight Gain
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Summary:	A progesterone antagonist (RU 486), combined with oxytocin, was effective in achieving cervical dilation, labor induction, and early delivery in near-term monkeys. Effects of RU 486 included accelerated flow of colostrum and transiently enhanced weight gain in infants. No overt toxicity on fetuses, mothers, or newborns was detected with the use of a single oral dose of 25 mg.
ISSN:	0002-9378
DOI:	10.1016/0002-9378(89)90084-7