Flumazenil (Ro15-1788) does not affect ethanol tolerance and dependence

There are conflicting reports concerning whether flumazenil (Ro15-1788) can antagonize the central effects of ethanol and ethanol withdrawal reactions. C57BL/6J mice were treated chronically with an ethanol liquid diet. Control mice were pair fed an isocaloric diet containing no ethanol. These mice...

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Bibliographic Details
Published in:	Pharmacology, biochemistry and behavior Vol. 39; no. 3; p. 659
Main Authors:	Chan, A W, Leong, F W, Schanley, D L, Langan, M C, Penetrante, F
Format:	Journal Article
Language:	English
Published:	United States 01-07-1991
Subjects:	Animals Ataxia - chemically induced Ataxia - prevention & control Behavior, Animal - drug effects Body Temperature - drug effects Diet Drug Tolerance Ethanol - administration & dosage Ethanol - pharmacology Flumazenil - pharmacology Handling (Psychology) Injections, Intraperitoneal Male Mice Mice, Inbred C57BL Seizures - etiology Substance Withdrawal Syndrome - psychology Substance-Related Disorders - psychology
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