A new bradykinin-potentiating peptide (peptide P) isolated from the venom of Bothrops jararacussu (jararacuçu tapete, urutu dourado)

Several bradykinin potentiators were identified in the venom of Bothrops jararacussu by chromatographic techniques and biological assays. One of them which was isolated inhibited the angiotensin-converting enzyme in vitro and potentiated the bradykinin-induced lowering of the arterial pressure in th...

Full description

Saved in:

Bibliographic Details
Published in:	Toxicon (Oxford) Vol. 30; no. 1; p. 33
Main Authors:	Ferreira, L A, Henriques, O B, Lebrun, I, Batista, M B, Prezoto, B C, Andreoni, A S, Zelnik, R, Habermehl, G
Format:	Journal Article
Language:	English
Published:	England 01-01-1992
Subjects:	Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Blood Pressure - drug effects Bradykinin - pharmacology Captopril - pharmacology Chromatography, Gel Chromatography, High Pressure Liquid Crotalid Venoms - chemistry Crotalid Venoms - pharmacology Drug Synergism Female Guinea Pigs Ileum Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Oligopeptides - chemistry Oligopeptides - isolation & purification Oligopeptides - pharmacology Organ Culture Techniques Rats Snakes
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Several bradykinin potentiators were identified in the venom of Bothrops jararacussu by chromatographic techniques and biological assays. One of them which was isolated inhibited the angiotensin-converting enzyme in vitro and potentiated the bradykinin-induced lowering of the arterial pressure in the rat.
ISSN:	0041-0101
DOI:	10.1016/0041-0101(92)90499-U