Effects of footshock stress and morphine on natural killer lymphocytes in rats: studies of tolerance and cross-tolerance

Exposure to a form of footshock stress known to cause opioid-mediated analgesia suppresses the cytotoxic activity of natural killer (NK) cells in rats. This suppression is blocked by the opioid antagonist, naltrexone and is mimicked by morphine administration, suggesting mediation by opioid receptor...

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Bibliographic Details
Published in:	Brain research Vol. 372; no. 2; p. 382
Main Authors:	Shavit, Y, Terman, G W, Lewis, J W, Zane, C J, Gale, R P, Liebeskind, J C
Format:	Journal Article
Language:	English
Published:	Netherlands 07-05-1986
Subjects:	Animals Brain - physiology Cytotoxicity, Immunologic Drug Tolerance Electroshock Female Foot Killer Cells, Natural - immunology Morphine - pharmacology Rats Rats, Inbred F344 Receptors, Opioid - physiology Stress, Physiological - immunology
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Summary:	Exposure to a form of footshock stress known to cause opioid-mediated analgesia suppresses the cytotoxic activity of natural killer (NK) cells in rats. This suppression is blocked by the opioid antagonist, naltrexone and is mimicked by morphine administration, suggesting mediation by opioid receptors. Supporting this hypothesis, we now report that the morphine-induced suppression of NK activity shows tolerance after 14 daily injections. The NK-suppressive effect of stress, however, shows neither tolerance with repetition nor cross-tolerance in morphine-tolerant rats.
ISSN:	0006-8993
DOI:	10.1016/0006-8993(86)91149-2