Deciphering Structure–Activity Relationships in a Series of 2,2‐Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants

4,6‐Disubstituted 2,2‐dimethylchromans are reported as pharmacologically active compounds that mainly target the ATP‐sensitive potassium channels. The present study is an attempt to characterize the impact of the nature of substituents introduced at the 4‐ and 6‐positions of 2,2‐dimethylchromans on...

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Bibliographic Details
Published in:	ChemMedChem Vol. 12; no. 21; pp. 1810 - 1817
Main Authors:	Pirotte, Bernard, Florence, Xavier, Goffin, Eric, Lebrun, Philippe
Format:	Journal Article Web Resource
Language:	English
Published:	Germany Wiley Subscription Services, Inc 08-11-2017 John Wiley and Sons Ltd
Subjects:	Animals Aorta Aorta - drug effects Aorta - physiology Beta cells Biochemistry Calcium Calcium influx Cells, Cultured chromans Chromans - chemistry Chromans - pharmacology Drug Discovery General Pharmacology, Toxicology and Pharmaceutics Human health sciences Insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Ion channels medicinal chemistry Molecular Medicine Muscle relaxants Muscle, Smooth, Vascular Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Neuromuscular Agents Neuromuscular Agents - chemistry Neuromuscular Agents - pharmacology Organic Chemistry Pancreas Pharmacie, pharmacologie & toxicologie Pharmacology Pharmacology, Toxicology and Pharmaceutics (all) Pharmacy, pharmacology & toxicology Potassium Potassium channels Rats Rats, Wistar Sciences de la santé humaine Smooth muscle Steric hindrance Structure-Activity Relationship Structure-activity relationships substituent effects structure-activity relationships substituent effects ion channels medicinal chemistry chromans
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