Enhancement of TRAIL/Apo2L‐mediated apoptosis by adriamycin through inducing DR4 and DR5 in renal cell carcinoma cells

Renal cell carcinoma (RCC) is one of the most drug‐resistant malignancies in humans. We show that adriamycin (ADR) and TNF‐related apoptosis‐inducing ligand (TRAIL)/Apo2L have a synergistic cytotoxic effect against RCC cells. This synergistic cytotoxicity was obtained in ACHN, A704, Caki‐1 and Caki‐...

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Bibliographic Details
Published in:	International journal of cancer Vol. 104; no. 4; pp. 409 - 417
Main Authors:	Wu, Xiu‐Xian, Kakehi, Yoshiyuki, Mizutani, Youichi, Nishiyama, Hiroyuki, Kamoto, Toshiyuki, Megumi, Yuzuru, Ito, Noriyuki, Ogawa, Osamu
Format:	Journal Article
Language:	English
Published:	New York Wiley Subscription Services, Inc., A Wiley Company 20-04-2003 Wiley-Liss
Subjects:	ADR Antineoplastic agents apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins Biological and medical sciences Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - pathology Caspases - physiology Doxorubicin - pharmacology DR4 DR5 Drug Synergism General aspects Humans Kidney Neoplasms - drug therapy Kidney Neoplasms - pathology Medical sciences Membrane Glycoproteins - pharmacology Pharmacology. Drug treatments RCC Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, Tumor Necrosis Factor - biosynthesis TNF-Related Apoptosis-Inducing Ligand TRAIL Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology Kidney disease Antineoplastic agent Human Drug combination Urinary system disease Carcinoma Cytokine Malignant tumor Doxorubicin In vitro Biological activity Kidney Antibiotic Tumor necrosis factor Cell death Established cell line Grawitz tumor TNF related apoptosis inducing ligand Anthracyclins Drug interaction Apoptosis Biological receptor
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