Melatonin as adjunctive therapy in the treatment of periodontitis associated with obesity

Aims To study the effect of adjunctive systemic administration of melatonin to standard mechanical periodontal therapy in obese rats with experimental periodontitis. Materials and methods In 42 Wistar rats with an initial body weight of 180 g., half (n = 21) were fed with a high‐fat diet to induce o...

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Bibliographic Details
Published in:	Journal of clinical periodontology Vol. 45; no. 11; pp. 1336 - 1346
Main Authors:	Virto, Leire, Cano, Pilar, Jiménez‐Ortega, Vanesa, Fernández‐Mateos, Pilar, González, Jerián, Haugen, Håvard J., Esquifino, Ana Isabel, Sanz, Mariano
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-11-2018 Munksgaard Forlag
Subjects:	Alveolar bone Biomarkers Body weight Bone healing Bone loss Bone resorption Cell adhesion Chlorhexidine circadian rhythms Cytokines Dentistry Gingiva Gingival index Gum disease High fat diet Inflammation Insulin Intercellular adhesion molecule 1 Leptin Lipids Melatonin Morbidity Obesity Osteocalcin Osteopontin Periodontitis Plasminogen activator inhibitors Rodents chlorhexidine circadian rhythms melatonin inflammation obesity periodontitis
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