Reduction of cyclosporine dosage with ketoconazole in a patient with birdshot retinochoroidopathy

• Published in: American journal of ophthalmology Vol. 125; no. 1; pp. 106 - 108
• Main Authors: Silverstein, Bruce E., Wong, Ira G.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 1998; Elsevier; Elsevier Limited
• Subjects: Biological and medical sciences; Chemotherapy, Adjuvant; Choroid Diseases - drug therapy; Choroid Diseases - physiopathology; Cyclosporine - administration & dosage; Cyclosporine - therapeutic use; Drug Therapy, Combination; Eye; Female; Humans; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - therapeutic use; Ketoconazole - therapeutic use; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Retinal Diseases - drug therapy; Retinal Diseases - physiopathology; Safety; Uveitis, Posterior - drug therapy; Uveitis, Posterior - physiopathology; Case study; Human; Imidazole derivatives; Eye disease; Chemotherapy; Ketoconazole; Posterior; Adjuvant treatment; Uveitis; Uvea disease; Ciclosporin; Immunosuppressive agent
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/S0002-9394(99)80246-3

To report the successful reduction of cyclosporine dosage with adjunctive ketoconazole in a patient with birdshot retinochoriodopathy.
Case report.
A 55-year-old woman treated with cyclosporine for birdshot retinochoroidopathy had ketoconazole (200 mg/day) added to her medical regimen. Her cyclosporine dosage was reduced to 40 mg per day from 200 mg per day, an 80% reduction. No toxic effect was observed during 12 months of follow-up nor was there progression of the birdshot retinochoroidopathy.
Cyclosporine dosage may be reduced considerably in patients with uveitis who use adjunctive ketoconazole. The regimen appears to be safe and efficacious.