Indocyanine Green Videoangiography After Acute Retinal Pigment Epithelial Tears in Age-related Macular Degeneration

• Published in: American journal of ophthalmology Vol. 123; no. 3; pp. 377 - 385
• Main Authors: ARROYO, JORGE G., SCHATZ, HOWARD, MCDONALD, RICHARD, JOHNSON, ROBERT N.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-03-1997; Elsevier; Elsevier Limited
• Subjects: Acute Disease; Aged; Aged, 80 and over; Biological and medical sciences; Female; Fluorescein Angiography; Fundus Oculi; Humans; Indocyanine Green; Investigative techniques, diagnostic techniques (general aspects); Macular Degeneration - complications; Male; Medical sciences; Otorhinolaryngology. Stomatology. Orbit; Pigment Epithelium of Eye - pathology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Retinal Perforations - etiology; Retinal Perforations - pathology; Visual Acuity; Human; Retinal detachment; Retinopathy; Radiodiagnosis; Angiography; Radiologic sign; Pigment epithelium; Maculopathy; Indocyanine green; Macula; Eye disease; Fluorescein; Degeneration; Age; Comparative study
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/S0002-9394(14)70134-5

To determine the features of combined fluorescein and indocyanine green videoangiography after acute retinal pigment epithelial tears associated with age-related macular degeneration.
We performed combined fluorescein and indocyanine green videoangiography in three eyes of three patients 2 days to 2 months after the development of tears of the retinal pigment epithelium.
The area of exposed choroid in a retinal pigment epithelial tear shows intense hyperfluorescence in fluorescein videoangiography; in contrast, this area demonstrates near-normal choroidal fluorescence on an indocyanine green videoangiogram. The folded and retracted flap of retinal pigment epithelium in a retinal pigment epithelial tear discloses marked hypofluorescence on the fluorescein videoangiogram; in contrast, this flap of retinal pigment epithelium displays varying degrees of hyperfluorescence on the indocyanine green videoangiogram.
The angiographic differences between fluorescein and indocyanine green result from the distinct biophysical properties of these two dyes as well as from the differential penetration of their fluorescence through such pigmented structures as retinal pigment epithelium. Compared with fluorescein videoangiography, indocyanine green videoangiography allows better visualization of choroidal neovascular membranes within the rolled-up and retracted flap of the retinal pigment epithelial tear.