Co-administration of cyclosporin enables oral therapy with paclitaxel

Terwogt et al determined whether co-administration of cyclosporin (Cs) might increase the absorption of oral paclitaxel. Co-administration of the P-gp inhibitor Cs increases absorption of oral paclitaxel to therapeutic plasma concentrations.

Saved in:

Bibliographic Details
Published in:	The Lancet (British edition) Vol. 352; no. 9124; p. 285
Main Authors:	Terwogt, Jetske M Meerum, Beijnen, Jos H, Huinink, Wim W ten Bokkel, Rosing, Hilde, Schellens, Jan HM
Format:	Journal Article
Language:	English
Published:	London Elsevier Ltd 25-07-1998 Lancet Elsevier Limited
Subjects:	Absorption Administration, Oral Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacokinetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors Biological and medical sciences Biological Availability Chemotherapy Cyclosporine - administration & dosage Drug therapy Drug Therapy, Combination Humans Infusions, Intravenous Medical sciences Mice Mice, Knockout Neoplasms - drug therapy Paclitaxel - administration & dosage Paclitaxel - pharmacokinetics Pharmacology. Drug treatments Side effects Antineoplastic agent Human Antibiotic Chemotherapy Counter indication Association Treatment Intravenous administration Taxane derivatives Paclitaxel Oral administration Antimitotic
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Terwogt et al determined whether co-administration of cyclosporin (Cs) might increase the absorption of oral paclitaxel. Co-administration of the P-gp inhibitor Cs increases absorption of oral paclitaxel to therapeutic plasma concentrations.
Bibliography:	SourceType-Other Sources-1 ObjectType-Article-2 ObjectType-Feature-1 ObjectType-Correspondence-3 content type line 66 ObjectType-News-4
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(98)24030-X