Familial multiple sclerosis in a Brazilian sample: Is HLA-DR15 involved in susceptibility to the disease?

• Published in: Journal of neuroimmunology Vol. 330; pp. 74 - 80
• Main Authors: da Silva Bernardes, Melina, Antão Paiva, Carmen Lucia, Ribeiro Paradela, Eduardo, Papais Alvarenga, Marcos, Ferreira Pereira, Fernanda, Vasconcelos, Claudia Cristina, Papais Alvarenga, Regina Maria
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15-05-2019
• Subjects: Brazilians; Familial; HLA-DR15; HLA-DRB1; Multiple sclerosis; Susceptibility; HLA-DR15; Multiple sclerosis; Brazilians; Susceptibility; Familial; HLA-DRB1
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2019.02.004

The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS). The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated with the susceptibility to MS familial forms (MSf) in an admixed Brazilian population.
Association analyses between DR15 and the clinical and demographic variables were made.
We have genotyped 25 familial cases. The DR15 was detected in 11/25 (44%) of them and in none of controls (P < .00001). DR15 was significantly associated to a foreign ancestor background (P = .029) and later age of onset (P = .018).
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•HLA-DR15 haplotype is associated with familial multiple sclerosis in Brazilians.•Patients with HLA-DR15 showed later age of onset of multiple sclerosis.•HLA-DR15 was associated with Caucasian (European) ancestry.