Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1
Fibroblast growth factor receptors (FGFRs) are integral membrane proteins involved in various biological processes including proliferation, migration and apoptosis. There are a number of regulatory mechanisms of FGFR signaling, which tightly control the specificity and duration of transmitted signal...
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| Published in: | International journal of biological macromolecules Vol. 180; pp. 470 - 483 |
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01-06-2021
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| Abstract | Fibroblast growth factor receptors (FGFRs) are integral membrane proteins involved in various biological processes including proliferation, migration and apoptosis. There are a number of regulatory mechanisms of FGFR signaling, which tightly control the specificity and duration of transmitted signals. The effect of the FGFRs spatial distribution in the plasma membrane on receptor-dependent functions is still largely unknown.
We have demonstrated that oligomerization of FGF1 with coiled-coil motifs largely improves FGF1 affinity for FGFRs and heparin. Set of developed FGF1 oligomers evoked prolonged activation of FGFR1 and receptor-downstream signaling pathways, as compared to the wild type FGF1. The majority of obtained oligomeric FGF1 variants showed increased stability, enhanced mitogenic activity and largely improved internalization via FGFR1-dependent endocytosis. Importantly, FGF1 oligomers with the highest oligomeric state exhibited reduced ability to stimulate FGFR-dependent glucose uptake, while at the same time remained hyperactive in the induction of cell proliferation. Our data implicate that oligomerization of FGF1 alters the biological activity of the FGF/GFR1 signaling system. Furthermore, developed FGF1 oligomers, due to improved stability and proliferative potential, can be applied in the regenerative medicine or as drug delivery vehicles in the ADC approach against FGFR1-overproducing cancers. |
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| AbstractList | Fibroblast growth factor receptors (FGFRs) are integral membrane proteins involved in various biological processes including proliferation, migration and apoptosis. There are a number of regulatory mechanisms of FGFR signaling, which tightly control the specificity and duration of transmitted signals. The effect of the FGFRs spatial distribution in the plasma membrane on receptor-dependent functions is still largely unknown. We have demonstrated that oligomerization of FGF1 with coiled-coil motifs largely improves FGF1 affinity for FGFRs and heparin. Set of developed FGF1 oligomers evoked prolonged activation of FGFR1 and receptor-downstream signaling pathways, as compared to the wild type FGF1. The majority of obtained oligomeric FGF1 variants showed increased stability, enhanced mitogenic activity and largely improved internalization via FGFR1-dependent endocytosis. Importantly, FGF1 oligomers with the highest oligomeric state exhibited reduced ability to stimulate FGFR-dependent glucose uptake, while at the same time remained hyperactive in the induction of cell proliferation. Our data implicate that oligomerization of FGF1 alters the biological activity of the FGF/GFR1 signaling system. Furthermore, developed FGF1 oligomers, due to improved stability and proliferative potential, can be applied in the regenerative medicine or as drug delivery vehicles in the ADC approach against FGFR1-overproducing cancers. Fibroblast growth factor receptors (FGFRs) are integral membrane proteins involved in various biological processes including proliferation, migration and apoptosis. There are a number of regulatory mechanisms of FGFR signaling, which tightly control the specificity and duration of transmitted signals. The effect of the FGFRs spatial distribution in the plasma membrane on receptor-dependent functions is still largely unknown. We have demonstrated that oligomerization of FGF1 with coiled-coil motifs largely improves FGF1 affinity for FGFRs and heparin. Set of developed FGF1 oligomers evoked prolonged activation of FGFR1 and receptor-downstream signaling pathways, as compared to the wild type FGF1. The majority of obtained oligomeric FGF1 variants showed increased stability, enhanced mitogenic activity and largely improved internalization via FGFR1-dependent endocytosis. Importantly, FGF1 oligomers with the highest oligomeric state exhibited reduced ability to stimulate FGFR-dependent glucose uptake, while at the same time remained hyperactive in the induction of cell proliferation. Our data implicate that oligomerization of FGF1 alters the biological activity of the FGF/GFR1 signaling system. Furthermore, developed FGF1 oligomers, due to improved stability and proliferative potential, can be applied in the regenerative medicine or as drug delivery vehicles in the ADC approach against FGFR1-overproducing cancers. |
| Author | Jastrzebski, Kamil Knapik, Agata Kucinska, Marika Otlewski, Jacek Czyrek, Aleksandra Porebska, Natalia Pozniak, Marta Opalinski, Lukasz Zakrzewska, Malgorzata Krzyscik, Mateusz Adam |
| Author_xml | – sequence: 1 givenname: Natalia surname: Porebska fullname: Porebska, Natalia organization: Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland – sequence: 2 givenname: Marta surname: Pozniak fullname: Pozniak, Marta organization: Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland – sequence: 3 givenname: Mateusz Adam surname: Krzyscik fullname: Krzyscik, Mateusz Adam organization: Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland – sequence: 4 givenname: Agata surname: Knapik fullname: Knapik, Agata organization: Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland – sequence: 5 givenname: Aleksandra surname: Czyrek fullname: Czyrek, Aleksandra organization: Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland – sequence: 6 givenname: Marika surname: Kucinska fullname: Kucinska, Marika organization: Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland – sequence: 7 givenname: Kamil surname: Jastrzebski fullname: Jastrzebski, Kamil organization: Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Warsaw 02-109, Poland – sequence: 8 givenname: Malgorzata surname: Zakrzewska fullname: Zakrzewska, Malgorzata organization: Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland – sequence: 9 givenname: Jacek surname: Otlewski fullname: Otlewski, Jacek organization: Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland – sequence: 10 givenname: Lukasz surname: Opalinski fullname: Opalinski, Lukasz email: lukasz.opalinski@uwr.edu.pl organization: Faculty of Biotechnology, Department of Protein Engineering, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33745974$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_apsb_2024_01_009 crossref_primary_10_1016_j_ijbiomac_2022_07_105 crossref_primary_10_1038_s41467_023_36895_1 crossref_primary_10_1016_j_biotechadv_2023_108213 crossref_primary_10_1021_acs_biomac_1c01280 crossref_primary_10_1186_s12964_023_01203_3 crossref_primary_10_1186_s12929_021_00767_x crossref_primary_10_1186_s12964_023_01144_x crossref_primary_10_3390_biom11081088 |
| Cites_doi | 10.1038/s41598-017-07479-z 10.1016/j.cell.2013.03.013 10.1038/386288a0 10.3389/fendo.2015.00154 10.1093/hmg/ddi161 10.1038/nrm3528 10.1038/nrc.2017.8 10.1038/ncomms10262 10.1016/j.jmb.2005.07.066 10.1038/ncomms13301 10.1101/cshperspect.a015958 10.1242/jcs.02509 10.2147/DDDT.S105896 10.1016/j.tibs.2016.10.007 10.1038/nm.4101 10.1038/s41571-018-0115-y 10.1039/c3mb70073a 10.3803/EnM.2016.31.3.361 10.1042/CS20140100 10.1002/wdev.176 10.1002/1878-0261.12740 10.1016/j.pep.2014.03.012 10.3390/cells8050455 10.1016/j.ctrv.2016.03.015 10.1038/nrd2792 10.1021/acs.chemrev.0c00981 10.1039/C9CS00473D 10.1002/pmic.200700615 10.1101/gad.13.11.1361 10.1074/jbc.M109.001289 10.1016/j.molmet.2021.101175 10.3390/ijms21114108 10.1038/nrm1399 10.1242/jcs.116228 10.1021/acs.bioconjchem.7b00158 10.1186/s12964-019-0371-1 10.1039/C7ME00012J 10.3390/cells10010129 10.1371/journal.pone.0021708 10.1038/nature13540 10.1242/jcs.017160 10.1158/1541-7786.MCR-16-0136 |
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| Keywords | Cell division Signaling Oligomerization Protein transport Metabolism FGFR |
| Language | English |
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| References | Beenken, Mohammadi (bb0025) 2009; 8 Itoh, Ohta, Konishi (bb0065) 2015; 6 Nawrocka, Krzyscik, Opaliński, Zakrzewska, Otlewski (bb0085) 2020; 21 Cristie-David, Sciore, Badieyan, Escheweiler, Koldewey, Bardwell, Ruotolo, Marsh (bb0145) 2017; 2 Vecchione, Cooper, Trim, Akbarzadeh, Heath, Wheldon (bb0080) 2007; 7 Kozer, Barua, Orchard, Nice, Burgess, Hlavacek, Clayton (bb0175) 2013; 9 Hubbard (bb0170) 2004; 5 Donato, Wasinski, Furigo, Metzger, Frazão (bb0210) 2021 Shi, Rampello, Glynn (bb0150) 2016; 7 Katoh (bb0035) 2019; 16 Pozniak, Sokolowska-Wedzina, Jastrzebski, Szymczyk, Porebska, Krzyscik, Zakrzewska, Miaczynska, Otlewski, Opalinski (bb0110) 2020 Sokolowska-Wedzina, Chodaczek, Chudzian, Borek, Zakrzewska, Otlewski (bb0165) 2017; 15 Ornitz, Itoh (bb0010) 2015; 4 Szlachcic, Zakrzewska, Lobocki, Jakimowicz, Otlewski (bb0195) 2016; 10 Mahatma, Bhatnagar, Mittal, Mahatma (bb0135) 2011 Sarabipour, Hristova (bb0090) 2016; 7 Haugsten, Sørensen, Brech, Olsnes, Wesche (bb0100) 2005; 118 Li, Wang, Tian, Zhou, Li, Yang (bb0185) 2020; 49 Krejci, Salazar, Goodridge, Kashiwada, Schibler, Jelinkova, Thompson, Wilcox (bb0045) 2008 Zakrzewska, Krowarsch, Wiedlocha, Olsnes, Otlewski (bb0125) 2005; 352 Richards, Thornberry, Pinto (bb0215) 2021 Hallinan, Finn, Cuffe, Rafee, O’Byrne, Gately (bb0030) 2016; 46 Auciello, Cunningham, Tatar, Heath, Rappoport (bb0095) 2013; 126 Opaliński, Sokołowska-Wȩdzina, Szczepara, Zakrzewska, Otlewski (bb0115) 2017; 7 Babina, Turner (bb0020) 2017; 17 Gavrieli, Mantzoros (bb0205) 2016 Belov, Mohammadi (bb0070) 2013; 5 Suh, Jonker, Ahmadian, Goetz, Osborn, Huang, Liu, Yoshihara, Van Dijk, Fan, Yin, Yu, Liddle, Annette, Olefsky, Mohammadi, Downes, Ronald (bb0160) 2015; 513 Haugsten, Zakrzewska, Brech, Pust, Olsnes, Sandvig, Wesche (bb0105) 2011; 6 Goetz, Mohammadi (bb0015) 2013; 14 Nowroozi, Raffioni, Wang, Apostol, Bradshaw, Thompson (bb0040) 2005; 14 Mohammadi, Zinkle (bb0060) 2018; 7 Sokolowska-Wedzina, Borek, Chudzian, Jakimowicz, Zakrzewska, Otlewski (bb0130) 2014; 99 Milardi, Gazit, Radford, Xu, Gallardo, Caflisch, Westermark, Westermark, La Rosa, Ramamoorthy (bb0200) 2021 Lupas, Bassler (bb0140) 2017; 42 Lobocki, Zakrzewska, Szlachcic, Krzyscik, Sokolowska-Wedzina, Otlewski (bb0190) 2017; 28 Latko, Czyrek, Porębska, Kucińska, Otlewski, Zakrzewska, Opaliński (bb0075) 2019; 8 Su, Kitagawa, Xue, Xie, Garofalo, Cho, Deng, Horton, Fu (bb0050) 1997 Scarlett, Rojas, Matsen, Kaiyala, Stefanovski, Bergman, Nguyen, Dorfman, Lantier, Wasserman, Mirzadeh, Unterman, Morton, Schwartz (bb0220) 2016; 22 Kucińska, Porȩbska, Lampart, Latko, Knapik, Zakrzewska, Otlewski, Opaliński (bb0120) 2019; 17 Wu (bb0180) 2013; 153 Sahni, Ambrosetti, Mansukhani, Gertner, Levy, Basilico (bb0055) 1999 Zakrzewska, Wiedlocha, Szlachcic, Krowarsch, Otlewski, Olsnes (bb0155) 2009; 284 Coleman, Bruce, Chioni, Kocher, Grose (bb0005) 2014; 127 Suh, Jonker, Ahmadian, Goetz, Lackey, Osborn, Huang, Liu, Yoshihara, Van Dijk, Havinga, Fan, Yin, Yu, Liddle, Atkins, Olefsky, Mohammadi, Downes, Evans (bb0225) 2014; 513 Katoh (10.1016/j.ijbiomac.2021.03.094_bb0035) 2019; 16 Suh (10.1016/j.ijbiomac.2021.03.094_bb0160) 2015; 513 Babina (10.1016/j.ijbiomac.2021.03.094_bb0020) 2017; 17 Haugsten (10.1016/j.ijbiomac.2021.03.094_bb0105) 2011; 6 Nowroozi (10.1016/j.ijbiomac.2021.03.094_bb0040) 2005; 14 Itoh (10.1016/j.ijbiomac.2021.03.094_bb0065) 2015; 6 Scarlett (10.1016/j.ijbiomac.2021.03.094_bb0220) 2016; 22 Hubbard (10.1016/j.ijbiomac.2021.03.094_bb0170) 2004; 5 Lobocki (10.1016/j.ijbiomac.2021.03.094_bb0190) 2017; 28 Shi (10.1016/j.ijbiomac.2021.03.094_bb0150) 2016; 7 Opaliński (10.1016/j.ijbiomac.2021.03.094_bb0115) 2017; 7 Richards (10.1016/j.ijbiomac.2021.03.094_bb0215) 2021 Beenken (10.1016/j.ijbiomac.2021.03.094_bb0025) 2009; 8 Mohammadi (10.1016/j.ijbiomac.2021.03.094_bb0060) 2018; 7 Zakrzewska (10.1016/j.ijbiomac.2021.03.094_bb0155) 2009; 284 Latko (10.1016/j.ijbiomac.2021.03.094_bb0075) 2019; 8 Milardi (10.1016/j.ijbiomac.2021.03.094_bb0200) 2021 Su (10.1016/j.ijbiomac.2021.03.094_bb0050) 1997 Sarabipour (10.1016/j.ijbiomac.2021.03.094_bb0090) 2016; 7 Sokolowska-Wedzina (10.1016/j.ijbiomac.2021.03.094_bb0165) 2017; 15 Suh (10.1016/j.ijbiomac.2021.03.094_bb0225) 2014; 513 Sahni (10.1016/j.ijbiomac.2021.03.094_bb0055) 1999 Cristie-David (10.1016/j.ijbiomac.2021.03.094_bb0145) 2017; 2 Krejci (10.1016/j.ijbiomac.2021.03.094_bb0045) 2008 Goetz (10.1016/j.ijbiomac.2021.03.094_bb0015) 2013; 14 Coleman (10.1016/j.ijbiomac.2021.03.094_bb0005) 2014; 127 Belov (10.1016/j.ijbiomac.2021.03.094_bb0070) 2013; 5 Hallinan (10.1016/j.ijbiomac.2021.03.094_bb0030) 2016; 46 Gavrieli (10.1016/j.ijbiomac.2021.03.094_bb0205) 2016 Ornitz (10.1016/j.ijbiomac.2021.03.094_bb0010) 2015; 4 Nawrocka (10.1016/j.ijbiomac.2021.03.094_bb0085) 2020; 21 Pozniak (10.1016/j.ijbiomac.2021.03.094_bb0110) 2020 Zakrzewska (10.1016/j.ijbiomac.2021.03.094_bb0125) 2005; 352 Szlachcic (10.1016/j.ijbiomac.2021.03.094_bb0195) 2016; 10 Haugsten (10.1016/j.ijbiomac.2021.03.094_bb0100) 2005; 118 Mahatma (10.1016/j.ijbiomac.2021.03.094_bb0135) 2011 Li (10.1016/j.ijbiomac.2021.03.094_bb0185) 2020; 49 Lupas (10.1016/j.ijbiomac.2021.03.094_bb0140) 2017; 42 Donato (10.1016/j.ijbiomac.2021.03.094_bb0210) 2021 Sokolowska-Wedzina (10.1016/j.ijbiomac.2021.03.094_bb0130) 2014; 99 Wu (10.1016/j.ijbiomac.2021.03.094_bb0180) 2013; 153 Vecchione (10.1016/j.ijbiomac.2021.03.094_bb0080) 2007; 7 Kucińska (10.1016/j.ijbiomac.2021.03.094_bb0120) 2019; 17 Auciello (10.1016/j.ijbiomac.2021.03.094_bb0095) 2013; 126 Kozer (10.1016/j.ijbiomac.2021.03.094_bb0175) 2013; 9 |
| References_xml | – volume: 126 start-page: 613 year: 2013 end-page: 624 ident: bb0095 article-title: Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8 publication-title: J. Cell Sci. contributor: fullname: Rappoport – volume: 46 start-page: 51 year: 2016 end-page: 62 ident: bb0030 article-title: Targeting the fibroblast growth factor receptor family in cancer publication-title: Cancer Treat. Rev. contributor: fullname: Gately – volume: 22 start-page: 800 year: 2016 end-page: 806 ident: bb0220 article-title: Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents publication-title: Nat. Med. contributor: fullname: Schwartz – volume: 513 start-page: 436 year: 2015 end-page: 439 ident: bb0160 article-title: HHS Public Access contributor: fullname: Ronald – volume: 8 start-page: 235 year: 2009 end-page: 253 ident: bb0025 article-title: The FGF family: biology, pathophysiology and therapy publication-title: Nat. Rev. Drug Discov. contributor: fullname: Mohammadi – volume: 6 start-page: 1 year: 2015 end-page: 9 ident: bb0065 article-title: Endocrine FGFs: evolution, physiology, pathophysiology, and pharmacotherapy publication-title: Front. Endocrinol. (Lausanne) contributor: fullname: Konishi – volume: 15 start-page: 1040 year: 2017 end-page: 1050 ident: bb0165 article-title: High-affinity internalizing human scFv-Fc antibody for targeting FGFR1-overexpressing lung cancer publication-title: Mol. Cancer Res. contributor: fullname: Otlewski – volume: 21 start-page: 1 year: 2020 end-page: 18 ident: bb0085 article-title: Stable fibroblast growth factor 2 dimers with high pro-survival and mitogenic potential publication-title: Int. J. Mol. Sci. contributor: fullname: Otlewski – volume: 513 start-page: 436 year: 2014 end-page: 439 ident: bb0225 article-title: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer publication-title: Nature contributor: fullname: Evans – volume: 8 start-page: 455 year: 2019 ident: bb0075 article-title: Cross-talk between fibroblast growth factor receptors and other cell surface proteins publication-title: Cells contributor: fullname: Opaliński – volume: 118 start-page: 3869 year: 2005 end-page: 3881 ident: bb0100 article-title: Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors publication-title: J. Cell Sci. contributor: fullname: Wesche – volume: 17 start-page: 1 year: 2019 end-page: 16 ident: bb0120 article-title: Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins publication-title: Cell Commun. Signal. contributor: fullname: Opaliński – volume: 6 year: 2011 ident: bb0105 article-title: Clathrin- and dynamin-independent endocytosis of fgfr3 - implications for signalling publication-title: PLoS One contributor: fullname: Wesche – year: 1999 ident: bb0055 article-title: FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway publication-title: Genes Dev. contributor: fullname: Basilico – year: 2021 ident: bb0215 article-title: The gut-brain axis: identification of new therapeutic approaches for type 2 diabetes, obesity, and related disorders publication-title: Mol. Metab. contributor: fullname: Pinto – volume: 16 start-page: 105 year: 2019 end-page: 122 ident: bb0035 article-title: Fibroblast growth factor receptors as treatment targets in clinical oncology publication-title: Nat. Rev. Clin. Oncol. contributor: fullname: Katoh – volume: 99 start-page: 50 year: 2014 end-page: 57 ident: bb0130 article-title: Efficient production and purification of extracellular domain of human FGFR-Fc fusion proteins from Chinese hamster ovary cells publication-title: Protein Expr. Purif. contributor: fullname: Otlewski – volume: 42 start-page: 130 year: 2017 end-page: 140 ident: bb0140 article-title: Coiled coils – a model system for the 21st century publication-title: Trends Biochem. Sci. contributor: fullname: Bassler – volume: 9 start-page: 1849 year: 2013 end-page: 1863 ident: bb0175 article-title: Exploring higher-order EGFR oligomerisation and phosphorylation - a combined experimental and theoretical approach publication-title: Mol. BioSyst. contributor: fullname: Clayton – volume: 14 start-page: 1529 year: 2005 end-page: 1538 ident: bb0040 article-title: Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells publication-title: Hum. Mol. Genet. contributor: fullname: Thompson – year: 2021 ident: bb0200 article-title: Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes publication-title: Chem. Rev. contributor: fullname: Ramamoorthy – volume: 127 start-page: 217 year: 2014 end-page: 231 ident: bb0005 article-title: The ins and outs of fibroblast growth factor receptor signalling publication-title: Clin. Sci. contributor: fullname: Grose – volume: 7 start-page: 1 year: 2016 end-page: 12 ident: bb0150 article-title: Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane publication-title: Nat. Commun. contributor: fullname: Glynn – volume: 17 start-page: 318 year: 2017 end-page: 332 ident: bb0020 article-title: Advances and challenges in targeting FGFR signalling in cancer publication-title: Nat. Rev. Cancer contributor: fullname: Turner – year: 2016 ident: bb0205 article-title: Novel molecules regulating energy homeostasis: physiology and regulation by macronutrient intake and weight loss publication-title: Endocrinol. Metab. contributor: fullname: Mantzoros – volume: 284 start-page: 25388 year: 2009 end-page: 25403 ident: bb0155 article-title: Increased protein stability of FGF1 can compensate for its reduced affinity for heparin publication-title: J. Biol. Chem. contributor: fullname: Olsnes – volume: 7 start-page: 1 year: 2016 end-page: 12 ident: bb0090 article-title: Mechanism of FGF receptor dimerization and activation publication-title: Nat. Commun. contributor: fullname: Hristova – volume: 7 start-page: 4565 year: 2007 end-page: 4578 ident: bb0080 article-title: Protein partners in the life history of activated fibroblast growth factor receptors publication-title: Proteomics contributor: fullname: Wheldon – year: 2011 ident: bb0135 article-title: Antioxidant metabolism in pearl millet genotypes during compatible and incompatible interaction with downy mildew pathogen publication-title: Arch. Phytopathol. Plant Prot. contributor: fullname: Mahatma – volume: 153 start-page: 287 year: 2013 end-page: 292 ident: bb0180 article-title: Higher-order assemblies in a new paradigm of signal transduction publication-title: Cell contributor: fullname: Wu – volume: 28 start-page: 1850 year: 2017 end-page: 1858 ident: bb0190 article-title: High-yield site-specific conjugation of fibroblast growth factor 1 with monomethylauristatin e via cysteine flanked by basic residues publication-title: Bioconjug. Chem. contributor: fullname: Otlewski – volume: 5 start-page: 1 year: 2013 end-page: 24 ident: bb0070 article-title: Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology publication-title: Cold Spring Harb. Perspect. Biol. contributor: fullname: Mohammadi – year: 2020 ident: bb0110 article-title: FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization publication-title: Mol. Oncol. contributor: fullname: Opalinski – volume: 5 start-page: 464 year: 2004 end-page: 470 ident: bb0170 article-title: Juxtamembrane autoinhibition in receptor tyrosine kinases publication-title: Nat. Rev. Mol. Cell Biol. contributor: fullname: Hubbard – volume: 7 start-page: 1 year: 2018 end-page: 15 ident: bb0060 article-title: A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination [version 1; referees: 4 approved] publication-title: F1000Research contributor: fullname: Zinkle – volume: 49 start-page: 1545 year: 2020 end-page: 1568 ident: bb0185 article-title: Nongenetic engineering strategies for regulating receptor oligomerization in living cells publication-title: Chem. Soc. Rev. contributor: fullname: Yang – year: 1997 ident: bb0050 article-title: Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism publication-title: Nature contributor: fullname: Fu – volume: 7 start-page: 1 year: 2017 end-page: 12 ident: bb0115 article-title: Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity publication-title: Sci. Rep. contributor: fullname: Otlewski – year: 2008 ident: bb0045 article-title: STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes publication-title: J. Cell Sci. contributor: fullname: Wilcox – volume: 14 start-page: 166 year: 2013 end-page: 180 ident: bb0015 article-title: Exploring mechanisms of FGF signalling through the lens of structural biology publication-title: Nat. Rev. Mol. Cell. Biol. contributor: fullname: Mohammadi – volume: 10 start-page: 2547 year: 2016 end-page: 2560 ident: bb0195 article-title: Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy publication-title: Drug Des. Devel. Ther. contributor: fullname: Otlewski – volume: 4 start-page: 215 year: 2015 end-page: 266 ident: bb0010 article-title: The fibroblast growth factor signaling pathway publication-title: Wiley Interdiscip. Rev. Dev. Biol. contributor: fullname: Itoh – volume: 352 start-page: 860 year: 2005 end-page: 875 ident: bb0125 article-title: Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action publication-title: J. Mol. Biol. contributor: fullname: Otlewski – year: 2021 ident: bb0210 article-title: Central regulation of metabolism by growth hormone publication-title: Cells contributor: fullname: Frazão – volume: 2 start-page: 140 year: 2017 end-page: 148 ident: bb0145 article-title: Evaluation of: de novo -designed coiled coils as off-the-shelf components for protein assembly publication-title: Mol. Syst. Des. Eng. contributor: fullname: Marsh – volume: 7 start-page: 1 year: 2017 ident: 10.1016/j.ijbiomac.2021.03.094_bb0115 article-title: Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity publication-title: Sci. Rep. doi: 10.1038/s41598-017-07479-z contributor: fullname: Opaliński – volume: 153 start-page: 287 year: 2013 ident: 10.1016/j.ijbiomac.2021.03.094_bb0180 article-title: Higher-order assemblies in a new paradigm of signal transduction publication-title: Cell doi: 10.1016/j.cell.2013.03.013 contributor: fullname: Wu – year: 1997 ident: 10.1016/j.ijbiomac.2021.03.094_bb0050 article-title: Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism publication-title: Nature doi: 10.1038/386288a0 contributor: fullname: Su – volume: 6 start-page: 1 year: 2015 ident: 10.1016/j.ijbiomac.2021.03.094_bb0065 article-title: Endocrine FGFs: evolution, physiology, pathophysiology, and pharmacotherapy publication-title: Front. Endocrinol. (Lausanne) doi: 10.3389/fendo.2015.00154 contributor: fullname: Itoh – volume: 14 start-page: 1529 year: 2005 ident: 10.1016/j.ijbiomac.2021.03.094_bb0040 article-title: Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddi161 contributor: fullname: Nowroozi – volume: 14 start-page: 166 year: 2013 ident: 10.1016/j.ijbiomac.2021.03.094_bb0015 article-title: Exploring mechanisms of FGF signalling through the lens of structural biology publication-title: Nat. Rev. Mol. Cell. Biol. doi: 10.1038/nrm3528 contributor: fullname: Goetz – volume: 17 start-page: 318 year: 2017 ident: 10.1016/j.ijbiomac.2021.03.094_bb0020 article-title: Advances and challenges in targeting FGFR signalling in cancer publication-title: Nat. Rev. Cancer doi: 10.1038/nrc.2017.8 contributor: fullname: Babina – volume: 7 start-page: 1 year: 2016 ident: 10.1016/j.ijbiomac.2021.03.094_bb0090 article-title: Mechanism of FGF receptor dimerization and activation publication-title: Nat. Commun. doi: 10.1038/ncomms10262 contributor: fullname: Sarabipour – volume: 352 start-page: 860 year: 2005 ident: 10.1016/j.ijbiomac.2021.03.094_bb0125 article-title: Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2005.07.066 contributor: fullname: Zakrzewska – volume: 513 start-page: 436 year: 2015 ident: 10.1016/j.ijbiomac.2021.03.094_bb0160 contributor: fullname: Suh – volume: 7 start-page: 1 year: 2016 ident: 10.1016/j.ijbiomac.2021.03.094_bb0150 article-title: Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane publication-title: Nat. Commun. doi: 10.1038/ncomms13301 contributor: fullname: Shi – volume: 5 start-page: 1 year: 2013 ident: 10.1016/j.ijbiomac.2021.03.094_bb0070 article-title: Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a015958 contributor: fullname: Belov – volume: 118 start-page: 3869 year: 2005 ident: 10.1016/j.ijbiomac.2021.03.094_bb0100 article-title: Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors publication-title: J. Cell Sci. doi: 10.1242/jcs.02509 contributor: fullname: Haugsten – volume: 10 start-page: 2547 year: 2016 ident: 10.1016/j.ijbiomac.2021.03.094_bb0195 article-title: Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy publication-title: Drug Des. Devel. Ther. doi: 10.2147/DDDT.S105896 contributor: fullname: Szlachcic – volume: 42 start-page: 130 year: 2017 ident: 10.1016/j.ijbiomac.2021.03.094_bb0140 article-title: Coiled coils – a model system for the 21st century publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2016.10.007 contributor: fullname: Lupas – volume: 22 start-page: 800 year: 2016 ident: 10.1016/j.ijbiomac.2021.03.094_bb0220 article-title: Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents publication-title: Nat. Med. doi: 10.1038/nm.4101 contributor: fullname: Scarlett – volume: 16 start-page: 105 year: 2019 ident: 10.1016/j.ijbiomac.2021.03.094_bb0035 article-title: Fibroblast growth factor receptors as treatment targets in clinical oncology publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/s41571-018-0115-y contributor: fullname: Katoh – volume: 9 start-page: 1849 year: 2013 ident: 10.1016/j.ijbiomac.2021.03.094_bb0175 article-title: Exploring higher-order EGFR oligomerisation and phosphorylation - a combined experimental and theoretical approach publication-title: Mol. BioSyst. doi: 10.1039/c3mb70073a contributor: fullname: Kozer – year: 2016 ident: 10.1016/j.ijbiomac.2021.03.094_bb0205 article-title: Novel molecules regulating energy homeostasis: physiology and regulation by macronutrient intake and weight loss publication-title: Endocrinol. Metab. doi: 10.3803/EnM.2016.31.3.361 contributor: fullname: Gavrieli – volume: 7 start-page: 1 year: 2018 ident: 10.1016/j.ijbiomac.2021.03.094_bb0060 article-title: A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination [version 1; referees: 4 approved] publication-title: F1000Research contributor: fullname: Mohammadi – volume: 127 start-page: 217 year: 2014 ident: 10.1016/j.ijbiomac.2021.03.094_bb0005 article-title: The ins and outs of fibroblast growth factor receptor signalling publication-title: Clin. Sci. doi: 10.1042/CS20140100 contributor: fullname: Coleman – volume: 4 start-page: 215 year: 2015 ident: 10.1016/j.ijbiomac.2021.03.094_bb0010 article-title: The fibroblast growth factor signaling pathway publication-title: Wiley Interdiscip. Rev. Dev. Biol. doi: 10.1002/wdev.176 contributor: fullname: Ornitz – year: 2020 ident: 10.1016/j.ijbiomac.2021.03.094_bb0110 article-title: FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization publication-title: Mol. Oncol. doi: 10.1002/1878-0261.12740 contributor: fullname: Pozniak – volume: 99 start-page: 50 year: 2014 ident: 10.1016/j.ijbiomac.2021.03.094_bb0130 article-title: Efficient production and purification of extracellular domain of human FGFR-Fc fusion proteins from Chinese hamster ovary cells publication-title: Protein Expr. Purif. doi: 10.1016/j.pep.2014.03.012 contributor: fullname: Sokolowska-Wedzina – year: 2011 ident: 10.1016/j.ijbiomac.2021.03.094_bb0135 article-title: Antioxidant metabolism in pearl millet genotypes during compatible and incompatible interaction with downy mildew pathogen publication-title: Arch. Phytopathol. Plant Prot. contributor: fullname: Mahatma – volume: 8 start-page: 455 year: 2019 ident: 10.1016/j.ijbiomac.2021.03.094_bb0075 article-title: Cross-talk between fibroblast growth factor receptors and other cell surface proteins publication-title: Cells doi: 10.3390/cells8050455 contributor: fullname: Latko – volume: 46 start-page: 51 year: 2016 ident: 10.1016/j.ijbiomac.2021.03.094_bb0030 article-title: Targeting the fibroblast growth factor receptor family in cancer publication-title: Cancer Treat. Rev. doi: 10.1016/j.ctrv.2016.03.015 contributor: fullname: Hallinan – volume: 8 start-page: 235 year: 2009 ident: 10.1016/j.ijbiomac.2021.03.094_bb0025 article-title: The FGF family: biology, pathophysiology and therapy publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd2792 contributor: fullname: Beenken – year: 2021 ident: 10.1016/j.ijbiomac.2021.03.094_bb0200 article-title: Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.0c00981 contributor: fullname: Milardi – volume: 49 start-page: 1545 year: 2020 ident: 10.1016/j.ijbiomac.2021.03.094_bb0185 article-title: Nongenetic engineering strategies for regulating receptor oligomerization in living cells publication-title: Chem. Soc. Rev. doi: 10.1039/C9CS00473D contributor: fullname: Li – volume: 7 start-page: 4565 year: 2007 ident: 10.1016/j.ijbiomac.2021.03.094_bb0080 article-title: Protein partners in the life history of activated fibroblast growth factor receptors publication-title: Proteomics doi: 10.1002/pmic.200700615 contributor: fullname: Vecchione – year: 1999 ident: 10.1016/j.ijbiomac.2021.03.094_bb0055 article-title: FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway publication-title: Genes Dev. doi: 10.1101/gad.13.11.1361 contributor: fullname: Sahni – volume: 284 start-page: 25388 year: 2009 ident: 10.1016/j.ijbiomac.2021.03.094_bb0155 article-title: Increased protein stability of FGF1 can compensate for its reduced affinity for heparin publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.001289 contributor: fullname: Zakrzewska – year: 2021 ident: 10.1016/j.ijbiomac.2021.03.094_bb0215 article-title: The gut-brain axis: identification of new therapeutic approaches for type 2 diabetes, obesity, and related disorders publication-title: Mol. Metab. doi: 10.1016/j.molmet.2021.101175 contributor: fullname: Richards – volume: 21 start-page: 1 year: 2020 ident: 10.1016/j.ijbiomac.2021.03.094_bb0085 article-title: Stable fibroblast growth factor 2 dimers with high pro-survival and mitogenic potential publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21114108 contributor: fullname: Nawrocka – volume: 5 start-page: 464 year: 2004 ident: 10.1016/j.ijbiomac.2021.03.094_bb0170 article-title: Juxtamembrane autoinhibition in receptor tyrosine kinases publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1399 contributor: fullname: Hubbard – volume: 126 start-page: 613 year: 2013 ident: 10.1016/j.ijbiomac.2021.03.094_bb0095 article-title: Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8 publication-title: J. Cell Sci. doi: 10.1242/jcs.116228 contributor: fullname: Auciello – volume: 28 start-page: 1850 year: 2017 ident: 10.1016/j.ijbiomac.2021.03.094_bb0190 article-title: High-yield site-specific conjugation of fibroblast growth factor 1 with monomethylauristatin e via cysteine flanked by basic residues publication-title: Bioconjug. Chem. doi: 10.1021/acs.bioconjchem.7b00158 contributor: fullname: Lobocki – volume: 17 start-page: 1 year: 2019 ident: 10.1016/j.ijbiomac.2021.03.094_bb0120 article-title: Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins publication-title: Cell Commun. Signal. doi: 10.1186/s12964-019-0371-1 contributor: fullname: Kucińska – volume: 2 start-page: 140 year: 2017 ident: 10.1016/j.ijbiomac.2021.03.094_bb0145 article-title: Evaluation of: de novo -designed coiled coils as off-the-shelf components for protein assembly publication-title: Mol. Syst. Des. Eng. doi: 10.1039/C7ME00012J contributor: fullname: Cristie-David – year: 2021 ident: 10.1016/j.ijbiomac.2021.03.094_bb0210 article-title: Central regulation of metabolism by growth hormone publication-title: Cells doi: 10.3390/cells10010129 contributor: fullname: Donato – volume: 6 year: 2011 ident: 10.1016/j.ijbiomac.2021.03.094_bb0105 article-title: Clathrin- and dynamin-independent endocytosis of fgfr3 - implications for signalling publication-title: PLoS One doi: 10.1371/journal.pone.0021708 contributor: fullname: Haugsten – volume: 513 start-page: 436 year: 2014 ident: 10.1016/j.ijbiomac.2021.03.094_bb0225 article-title: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer publication-title: Nature doi: 10.1038/nature13540 contributor: fullname: Suh – year: 2008 ident: 10.1016/j.ijbiomac.2021.03.094_bb0045 article-title: STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes publication-title: J. Cell Sci. doi: 10.1242/jcs.017160 contributor: fullname: Krejci – volume: 15 start-page: 1040 year: 2017 ident: 10.1016/j.ijbiomac.2021.03.094_bb0165 article-title: High-affinity internalizing human scFv-Fc antibody for targeting FGFR1-overexpressing lung cancer publication-title: Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-16-0136 contributor: fullname: Sokolowska-Wedzina |
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