Synthesis and biodistribution studies of carbohydrate derivatives radiolabeled with technetium-99m

• Published in: Bioorganic & medicinal chemistry letters Vol. 20; no. 1; pp. 315 - 317
• Main Authors: de Barros, André Luís Branco, Cardoso, Valbert Nascimento, Mota, Luciene das Graças, Alves, Ricardo José
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 2010; Elsevier
• Subjects: Animals; Biological and medical sciences; Carbohydrates; Carbohydrates - chemical synthesis; Carbohydrates - chemistry; Carbohydrates - pharmacokinetics; Contrast media. Radiopharmaceuticals; Glycine - analogs & derivatives; Glycine - chemistry; Glycine - pharmacokinetics; Hepatic function; Isotope Labeling; Liver - metabolism; MAG 3; Medical sciences; Mice; Pharmacology. Drug treatments; Technetium Tc 99m Mertiatide - chemistry; Technetium Tc 99m Mertiatide - pharmacokinetics; Technetium-99m; Tissue Distribution; Carbohydrates; MAG 3; Hepatic function; Technetium-99m; Glucosamine; Intravenous administration; Peptides; Tripeptide; Liver function; Tissue; Technetium Complexes; Scintigraphic agent; Glycoside; Radioisotopic product; Chemical synthesis; Aminosugar; Radiolabelling; Rodentia; Organic ligand; Transition metal Complexes; Diagnostic agent; Vertebrata; MAG; Mammalia; Mouse; Aminoglycoside; Animal; Distribution
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2009.10.104

Synthesis of carbohydrate derivatives with mercaptoacetyltriglycine (MAG
3), radiolabeling with technetium-99m and biodistribution studies in mice.
Three carbohydrate derivatives, MAG
3-Gl, MAG
3-Ga, MAG
3-NG, were synthesized and radiolabeled in high yields. These substances were injected in health Swiss mice and their biodistribution were evaluated. Among them,
99mTc-MAG
3-Ga displayed higher accumulation in hepatic tissue, due to the presence of specific receptors in the liver for this carbohydrate. Thus, the use of
99mTc-MAG
3-Ga to assess hepatic function can be considered.