Ras activation is associated with Vitamin D receptor mRNA instability in HC11 mammary cells

HC11, a spontaneously immortalized murine mammary lineage maintains features of normal cells while HC11 H-ras transformed cells (HC11 ras) are tumorigenic. Ras transformation is associated with a lower Vitamin D receptor (VDR) mRNA content. Our goal was to investigate the mechanism underlying VDR mR...

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Bibliographic Details
Published in:	The Journal of steroid biochemistry and molecular biology Vol. 92; no. 1; pp. 89 - 95
Main Authors:	Rozenchan, Patricia B., Folgueira, Maria A.A.K., Katayama, Maria L.H., Snitcovsky, Igor M.L., Brentani, M. Mitzi
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01-09-2004 Elsevier Science
Subjects:	3' Untranslated Regions - genetics Animals Biological and medical sciences Cells, Cultured DNA Mutational Analysis Enzyme Activation Farnesyltransferase inhibitor Female Fundamental and applied biological sciences. Psychology Mammary cells Mammary Glands, Animal - cytology Mammary Glands, Animal - metabolism Mice mRNA stability Mutation - genetics ras Proteins - metabolism Receptors, Calcitriol - genetics RNA Stability - physiology RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic - genetics VDR transcriptional rate Vertebrates: endocrinology Vitamin D receptor Mammary cells Farnesyltransferase inhibitor Vitamin D receptor VDR transcriptional rate mRNA stability Vitamin D Enzyme Transferases Activation Farnesyl-diphosphate farnesyltransferase Biological receptor
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