Ras activation is associated with Vitamin D receptor mRNA instability in HC11 mammary cells
HC11, a spontaneously immortalized murine mammary lineage maintains features of normal cells while HC11 H-ras transformed cells (HC11 ras) are tumorigenic. Ras transformation is associated with a lower Vitamin D receptor (VDR) mRNA content. Our goal was to investigate the mechanism underlying VDR mR...
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| Published in: | The Journal of steroid biochemistry and molecular biology Vol. 92; no. 1; pp. 89 - 95 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Ltd
01-09-2004
Elsevier Science |
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| Abstract | HC11, a spontaneously immortalized murine mammary lineage maintains features of normal cells while HC11 H-ras transformed cells (HC11 ras) are tumorigenic. Ras transformation is associated with a lower Vitamin D receptor (VDR) mRNA content. Our goal was to investigate the mechanism underlying VDR mRNA differences between these cells. Although the VDR transcriptional rate measured by run-on assays did not differ between the cells, our data suggested a pos transcriptional mechanism involving higher VDR mRNA degradation in HC11 ras cells which was not due to mutations in its 3′-UTR region since sequences of mRNA obtained from HC11 and HC11 ras cells were identical. Treatment of HC11 ras cells with a farnesyltransferase inhibitor, which prevents ras activation, causing an enhancement of VDR mRNA levels, indicating an association between the ras signaling pathway and VDR mRNA instability. The present work suggests that the decreased mRNA levels in HC11 ras cells might in part be due to an early loss of stability. |
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| AbstractList | HC11, a spontaneously immortalized murine mammary lineage maintains features of normal cells while HC11 H-ras transformed cells (HC11 ras) are tumorigenic. Ras transformation is associated with a lower Vitamin D receptor (VDR) mRNA content. Our goal was to investigate the mechanism underlying VDR mRNA differences between these cells. Although the VDR transcriptional rate measured by run-on assays did not differ between the cells, our data suggested a pos transcriptional mechanism involving higher VDR mRNA degradation in HC11 ras cells which was not due to mutations in its 3'-UTR region since sequences of mRNA obtained from HC11 and HC11 ras cells were identical. Treatment of HC11 ras cells with a farnesyltransferase inhibitor, which prevents ras activation, causing an enhancement of VDR mRNA levels, indicating an association between the ras signaling pathway and VDR mRNA instability. The present work suggests that the decreased mRNA levels in HC11 ras cells might in part be due to an early loss of stability. |
| Author | Brentani, M. Mitzi Katayama, Maria L.H. Snitcovsky, Igor M.L. Rozenchan, Patricia B. Folgueira, Maria A.A.K. |
| Author_xml | – sequence: 1 givenname: Patricia B. surname: Rozenchan fullname: Rozenchan, Patricia B. – sequence: 2 givenname: Maria A.A.K. surname: Folgueira fullname: Folgueira, Maria A.A.K. – sequence: 3 givenname: Maria L.H. surname: Katayama fullname: Katayama, Maria L.H. – sequence: 4 givenname: Igor M.L. surname: Snitcovsky fullname: Snitcovsky, Igor M.L. – sequence: 5 givenname: M. Mitzi surname: Brentani fullname: Brentani, M. Mitzi email: mbrentani@lim24.fm.usp.br |
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| CitedBy_id | crossref_primary_10_1016_j_bpc_2016_11_008 crossref_primary_10_1016_j_mce_2011_05_020 crossref_primary_10_1038_onc_2016_77 crossref_primary_10_1016_j_jnutbio_2008_06_008 crossref_primary_10_1002_jcb_21896 crossref_primary_10_1359_jbmr_07s204 crossref_primary_10_1016_j_cellsig_2007_06_025 crossref_primary_10_1016_j_abb_2011_10_019 crossref_primary_10_1016_j_jsbmb_2017_01_008 crossref_primary_10_1210_en_2017_00238 |
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| Keywords | Mammary cells Farnesyltransferase inhibitor Vitamin D receptor VDR transcriptional rate mRNA stability Vitamin D Enzyme Transferases Activation Farnesyl-diphosphate farnesyltransferase Biological receptor |
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| SubjectTerms | 3' Untranslated Regions - genetics Animals Biological and medical sciences Cells, Cultured DNA Mutational Analysis Enzyme Activation Farnesyltransferase inhibitor Female Fundamental and applied biological sciences. Psychology Mammary cells Mammary Glands, Animal - cytology Mammary Glands, Animal - metabolism Mice mRNA stability Mutation - genetics ras Proteins - metabolism Receptors, Calcitriol - genetics RNA Stability - physiology RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic - genetics VDR transcriptional rate Vertebrates: endocrinology Vitamin D receptor |
| Title | Ras activation is associated with Vitamin D receptor mRNA instability in HC11 mammary cells |
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