Bicistronic retroviral vectors for combining myeloprotection with cell-surface marking

We have developed a retroviral vector coexpressing the multidrug-resistance 1 (MDR1) cDNA for inducing cancer drug resistance and the truncated version of the low-affinity nerve growth factor receptor (DeltaLNGFR) for cell-surface marking of transduced cells. The vector is based on the FMEV backbone...

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Bibliographic Details
Published in:	Gene therapy Vol. 6; no. 7; pp. 1222 - 1230
Main Authors:	HILDINGER, M, SCHILZ, A, ECKERT, H.-G, BOHN, W, FEHSE, B, ZANDER, A. R, OSTERTAG, W, BAUM, C
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-07-1999
Subjects:	Actin ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Biological and medical sciences Biotechnology CD34 antigen Cell surface Chemotherapy Cytostatic agents Drug Resistance, Multiple - genetics Flow Cytometry Fundamental and applied biological sciences. Psychology Gene expression Gene therapy Gene Transfer Techniques Genetic Markers Genetic Vectors - genetics Health. Pharmaceutical industry Hematopoietic stem cells Humans Industrial applications and implications. Economical aspects internal ribosome entry sites MDR1 protein Multidrug resistance P-Glycoprotein Polymerase Chain Reaction Progenitor cells Receptor, Nerve Growth Factor - genetics Retroviridae - genetics Retrovirus Stem Cells Tumor Cells, Cultured Antineoplastic agent Toxicity Retroviridae Gene expression Myeloid cell Cell surface Virus Vertebrata Chemotherapy Mammalia Secondary effect Gene therapy Protection Vector
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