High-throughput screening for Hsp90 ATPase inhibitors

Recently, we reported a useful assay for the determination of Hsp90 ATPase activity. Using this assay, high-throughput screening of ∼10,000 compounds was performed to determine the feasibility of this assay on large scale. Results from high-throughput screening indicated that the assay was reproduci...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 16; no. 11; pp. 3005 - 3008
Main Authors:	Avila, Christopher, Hadden, M. Kyle, Ma, Zeqiang, Kornilayev, Boris A., Ye, Qi-Zhuang, Blagg, Brian S.J.
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01-06-2006 Elsevier
Subjects:	Adenosine Triphosphatases - antagonists & inhibitors Adenosine Triphosphatases - metabolism Biological and medical sciences Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology High-throughput screening Hsp90 HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - metabolism Inhibitors Medical sciences Miscellaneous Molecular Structure Pharmacology. Drug treatments Hsp90 High-throughput screening Inhibitors High throughput screening Yeast Enzyme Chaperone Adenosinetriphosphatase Enzyme inhibitor Biological activity Signal transduction Heat shock protein Test method Hydrolases Large scale
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