Single-dose bromocriptine reverses cocaine craving

Thirteen hospitalized cocaine addicts complaining of cocaine craving were given a single dose of bromocriptine, a dopamine agonist, in a randomized, double-blind, placebo-controlled study design. Compared to placebo, bromocriptine caused a significant reduction in craving ratings. These data suggest...

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Bibliographic Details
Published in:	Psychiatry research Vol. 20; no. 4; p. 261
Main Authors:	Dackis, C A, Gold, M S, Sweeney, D R, Byron, Jr, J P, Climko, R
Format:	Journal Article
Language:	English
Published:	Ireland 01-04-1987
Subjects:	Adult Bromocriptine - administration & dosage Cocaine Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Male Psychological Tests Substance-Related Disorders - psychology Substance-Related Disorders - rehabilitation
Online Access:	Get more information
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Summary:	Thirteen hospitalized cocaine addicts complaining of cocaine craving were given a single dose of bromocriptine, a dopamine agonist, in a randomized, double-blind, placebo-controlled study design. Compared to placebo, bromocriptine caused a significant reduction in craving ratings. These data suggest that bromocriptine may be effective as a new, nonaddictive pharmacological treatment for cocaine addicts and support the notion that functional dopamine depletion occurs with chronic cocaine use. Open trials indicate that low-dose bromocriptine may be useful in cocaine detoxification.
ISSN:	0165-1781
DOI:	10.1016/0165-1781(87)90086-2