Endothelial Function of Patients with Morbid Obesity Submitted to Roux-en-Y Gastric Bypass With and Without Obstructive Sleep Apnea-Hypopnea Syndrome

• Published in: Obesity surgery Vol. 28; no. 11; pp. 3595 - 3603
• Main Authors: de Assunção Machado, Ana Cristina, da Silva, Antonio Marcos Vargas, Signori, Luis Ulisses, da Costa Alvarez, Glauco, Mottin, Claudio Corá
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-11-2018; Springer Nature B.V
• Subjects: Gastrointestinal surgery; Low density lipoprotein; Medicine; Medicine & Public Health; Original Contributions; Sleep apnea; Surgery; Weight control; Vascular endothelium; Flow-mediated dilation; Morbid obesity; Obstructive sleep apnea-hypopnea syndrome; Gastric bypass
• ISSN: 0960-8923; 1708-0428
• DOI: 10.1007/s11695-018-3403-9

Background
Obesity is associated with obstructive sleep apnea
-
hypopnea syndrome (OSA) and both induce endothelial dysfunction. However, the effect of OSA on endothelial function after bariatric surgery has not been investigated yet.
Objectives
This study aims to evaluate the impact of weight loss on endothelial function in patients with and without obstructive sleep apnea (OSA) in the first 6 months after bariatric surgery.
Setting
This study was conducted at a university hospital, in Brazil.
Methods
The sample consisted of 56 patients homogeneously divided into groups with and without OSA. All patients underwent Roux-en-Y gastric bypass (RYGB), and the diagnosis of OSA was performed by polysomnography. The patients were evaluated preoperatively and 6 months after surgery. The evaluations included anthropometric measures, electrical bioimpedance, clinical symptoms of OSA
,
and endothelial function (
f
low-mediated dilation). RYGB improved the anthropometric, bioimpedance, and endothelial function results in both groups.
Results
Patients presented a significant clinical improvement in OSA symptoms throughout the study. However, patients with OSA had an improvement in the endothelial function 2.5% lower (
p
 < 0.001) than patients without APNEA syndrome.
Conclusion
This study demonstrates that the existence of OSA prior to bariatric surgery interferes in the improvement of endothelial function.