Amphotericin B-Resistant Disseminated Cryptococcal Infection with Concurrent Cytomegalovirus Colitis in a Renal Transplant Recipient - A Case Report

• Published in: Indian journal of transplantation Vol. 16; no. 4; pp. 428 - 430
• Main Authors: Gaur, Mragank, Sethi, Jasmine, Prakash, Mahesh
• Format: Journal Article
• Language: English
• Published: Medknow Publications and Media Pvt. Ltd 01-10-2022; Wolters Kluwer Medknow Publications
• Subjects: Amphotericin B; amphotericin resistance; Antiparasitic agents; Care and treatment; Colitis; cryptococcosis; cytomegalovirus; Cytomegalovirus infections; Fluconazole; Health aspects; Infection; Kidneys; Mycoses; solid organ transplant; Transplantation
• ISSN: 2212-0017; 2212-0025
• DOI: 10.4103/ijot.ijot_31_21

Post renal transplant opportunistic infections always pose a challenge to the clinician due to the varied nonspecific clinical manifestations and prove fatal if not diagnosed and treated early. Here, we present a case report of a patient who was 22 years post renal transplantation with amphotericin-resistant disseminated cryptococcal infection concurrent with cytomegalovirus colitis treated successfully with oral fluconazole and ganciclovir. The clinician should always take into account the antibiotic susceptibility and culture sensitivity of cryptococcosis to diagnose this rare yet emerging phenomenon of azole resistance. Furthermore, to the best of our knowledge, this is the first reported case of amphotericin-resistant cryptococcosis in posttransplant setting.