A postmenopause-like model of ovariectomized Wistar rats to identify active principles of Erythrina lysistemon (Fabaceae)

• Published in: Fitoterapia Vol. 82; no. 7; pp. 939 - 949
• Main Authors: Mvondo, M.A., Njamen, D., Fomum, S. Tanee, Wandji, J., Vollmer, Günter
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-10-2011; Elsevier
• Subjects: Animals; Antiatherogenic; Atherosclerosis - blood; Atherosclerosis - etiology; Atherosclerosis - prevention & control; Biological and medical sciences; Cholesterol - blood; Cholesterol, HDL - blood; Erythrina; Erythrina - chemistry; estradiol; Estradiol - pharmacology; estrogenic properties; Estrogenicity; Estrogens - pharmacology; Estrogens - therapeutic use; Female; Flavanone; General pharmacology; Hot flushes; Isoflavone; Medical sciences; Models, Animal; Ovariectomy; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Postmenopause; Rats; Rats, Wistar; Reference Values; risk; uterus; Uterus - drug effects; vagina; Vagina - drug effects; Isoflavone; Hot flushes; Postmenopause; Flavanone; Estrogenicity; Antiatherogenic; Skin disease; Rat; Menopause; Cardiovascular disease; Isoflavone derivatives; Flavonoid; Hot flush; Medicinal plant; Vascular disease; Polyphenol; Anti-astherosclerotic; Dicotyledones; Angiospermae; Ovariectomy; Pharmacognosy; Rodentia; Flavanone derivatives; Vertebrata; Mammalia; Leguminosae; Animal; Plant origin; Phenols; Spermatophyta; Erythema
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2011.05.009

To determine whether the two major compounds of Erythrina lysistemon are active principles accounting for Erythrina estrogenic effects, we used a postmenopause-like model of ovariectomized Wistar rats to evaluate their effects on some menopausal problems. Ovariectomized rats were orally treated either with compound 1 or compound 2 at 1 and 10mg/kg BW for 28days. Estradiol valerate served as the reference substance. As results, compounds 1 and 2 displayed estrogen-like effects on the uterus and the vagina, and reduced atherogenic risks by decreasing the two assessed atherogenic parameters, the total cholesterol/HDL-cholesterol ratio and the atherogenic index of plasma.
Compounds 1 and 2 amelliorated some postmenopause-like problems in the rat model, and therefore might be the active principles of Erythrina lysistemon (Fabaceae). [Display omitted]