Concentration-effect relationship of intravenous lidocaine on the allodynia of Complex Regional Pain Syndrome types I and II

• Published in: Anesthesiology (Philadelphia) Vol. 92; no. 1; pp. 75 - 83
• Main Authors: WALLACE, M. S, RIDGEWAY, B. M, LEUNG, A. Y, GERAYLI, A, YAKSH, T. L
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 2000
• Subjects: Adult; Aged; Anesthetics, Local - administration & dosage; Anesthetics, Local - blood; Anesthetics, Local - therapeutic use; Anesthetics. Neuromuscular blocking agents; Biological and medical sciences; Blood Pressure - drug effects; Cold Temperature; Complex Regional Pain Syndromes - drug therapy; Complex Regional Pain Syndromes - etiology; Diphenhydramine - administration & dosage; Diphenhydramine - therapeutic use; Double-Blind Method; Female; Heart Rate - drug effects; Hot Temperature; Humans; Infusions, Intravenous; Lidocaine - administration & dosage; Lidocaine - blood; Lidocaine - therapeutic use; Male; Medical sciences; Middle Aged; Neuropharmacology; Pain - etiology; Pain Measurement; Pharmacology. Drug treatments; Allodynia; Human; Nervous system diseases; Causalgia; Intravenous administration; Reflex sympathetic dystrophy; Local anesthetic; Analgesia; Chemotherapy; Analgesic; Pain; Treatment; Activity concentration relation; Diseases of the autonomic nervous system; Organic amide; Lidocaine
• ISSN: 0003-3022; 1528-1175
• DOI: 10.1097/00000542-200001000-00017

Several lines of evidence suggest that neuropathic pain (including Complex Regional Pain Syndrome [CRPS] I and CRPS II) is mediated in part by an increase in the density of voltage-sensitive sodium channels in injured axons and the dorsal root ganglion of injured axons. This study sought to characterize the effects of intravenous lidocaine (a sodium channel blocker) on acute sensory thresholds within the painful area and the size of the painful area in patients suffering from CRPS I and II.
This study used a randomized, double-blind, placebo-controlled design in 16 subjects suffering from CRPS I and II with a prominent allodynia. Each subject received an intravenous infusion of lidocaine and diphenhydramine separated by 1 week. A computer-controlled infusion pump targeted stair-step increases in plasma levels of lidocaine of 1, 2, and 3 microg/ml. At baseline and at each plasma level, spontaneous and evoked pain scores and neurosensory testing within the painful area were measured. The neurosensory testing consisted of thermal thresholds, tactile thresholds and the area of allodynia to punctate, and stroking and thermal stimuli.
Intravenous lidocaine and diphenhydramine had no significant effect on the cool, warm, or cold pain thresholds. However, lidocaine caused a significant elevation of the hot pain thresholds in the painful area. Intravenous lidocaine caused a significantly decreased response to stroking and cool stimuli in the allodynic area. There was also a significant decrease in pain scores to cool stimuli at all plasma levels and the spontaneous pain at the highest plasma level.
This study demonstrates that intravenous lidocaine affects pain in response to cool stimuli more than mechanical pain in subjects with neuropathic pain. There is a lesser effect on spontaneous pain and pain induced by stroking stimuli and no effect on the pain induced by punctate stimuli.