Effect of Atypical Sleep EEG Patterns on Weaning From Prolonged Mechanical Ventilation

• Published in: Chest Vol. 165; no. 5; pp. 1111 - 1119
• Main Authors: Shaikh, Hameeda, Ionita, Ramona, Khan, Usman, Park, Youngsook, Jubran, Amal, Tobin, Martin J., Laghi, Franco
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-05-2024; American College of Chest Physicians
• Subjects: Aged; atypical sleep; brain dysfunction; Critical Care: Original Research; Delirium - diagnosis; Delirium - etiology; Delirium - physiopathology; Electroencephalography - methods; Female; Humans; Intensive Care Units; Male; Middle Aged; Polysomnography; prolonged mechanical ventilation; Respiration, Artificial - methods; Sleep - physiology; Time Factors; Ventilator Weaning - methods; Wakefulness - physiology; weaning; prolonged mechanical ventilation; CAM-ICU; AASM; PSG; LTACH; REM; brain dysfunction; weaning; EMG; atypical sleep
• ISSN: 0012-3692; 1931-3543; 1931-3543
• DOI: 10.1016/j.chest.2024.01.005

Approximately one-third of acute ICU patients display atypical sleep patterns that cannot be interpreted by using standard EEG criteria for sleep. Atypical sleep patterns have been associated with poor weaning outcomes in acute ICUs.
Do patients being weaned from prolonged mechanical ventilation experience atypical sleep EEG patterns, and are these patterns linked with weaning outcomes?
EEG power spectral analysis during wakefulness and overnight polysomnogram were performed on alert, nondelirious patients at a long-term acute care facility.
Forty-four patients had been ventilated for a median duration of 38 days at the time of the polysomnogram study. Eleven patients (25%) exhibited atypical sleep EEG. During wakefulness, relative EEG power spectral analysis revealed higher relative delta power in patients with atypical sleep than in patients with usual sleep (53% vs 41%; P < .001) and a higher slow-to-fast power ratio during wakefulness: 4.39 vs 2.17 (P < .001). Patients with atypical sleep displayed more subsyndromal delirium (36% vs 6%; P = .027) and less rapid eye movement sleep (4% vs 11% total sleep time; P < .02). Weaning failure was more common in the atypical sleep group than in the usual sleep group: 91% vs 45% (P = .013).
This study provides the first evidence that patients in a long-term acute care facility being weaned from prolonged ventilation exhibit atypical sleep EEG patterns that are associated with weaning failure. Patients with atypical sleep EEG patterns had higher rates of subsyndromal delirium and slowing of the wakeful EEG, suggesting that these two findings represent a biological signal for brain dysfunction.
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