Pedopeptins, novel inhibitors of LPS: Taxonomy of producing organism, fermentation, isolation, physicochemical properties and structural elucidation

• Published in: Journal of antibiotics Vol. 67; no. 3; pp. 243 - 251
• Main Authors: Hirota-Takahata, Yuki, Kozuma, Shiho, Kuraya, Nahoki, Fukuda, Daisuke, Nakajima, Mutsuo, Ando, Osamu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-03-2014; Nature Publishing Group
• Subjects: 631/181/2480; 631/250/256/1980; 631/45/535; 631/92/349; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Culture Media; Depsipeptides - chemistry; Depsipeptides - isolation & purification; Fermentation; Life Sciences; Lipopolysaccharide Receptors - metabolism; Lipopolysaccharides - antagonists & inhibitors; Lipopolysaccharides - metabolism; Medicinal Chemistry; Microbiology; Organic Chemistry; original-article; Pedobacter - chemistry; Peptides, Cyclic - chemistry; Peptides, Cyclic - isolation & purification; Physicochemical properties; Spectrum Analysis; pedopeptin; CD14; lipopolysaccharide; pedobacter
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/ja.2013.122

In the course of our screening for inhibitors of lipopolysaccharide (LPS) binding to cellular receptor CD14, potent inhibitory activity was detected in the cultured broth of
Pedobacter
sp. SANK 72003. Three active compounds, pedopeptin A, B and C, were isolated from the broth and their structures were elucidated by physicochemical and spectral data to be new cyclic depsipeptides.