Intracerebroventricular infusion of cytosine-arabinoside causes prepulse inhibition disruption

• Published in: Neuroreport Vol. 20; no. 4; pp. 371 - 377
• Main Authors: Lau, Benson W.M, Yau, Suk-Yu, Lee, Tatia M.C, Ching, Yick-Pang, Tang, Siu-Wa, So, Kwok-Fai
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 04-03-2009; Lippincott Williams & Wilkins
• Subjects: Analysis of Variance; Animals; Antidepressive Agents - pharmacology; Behavioral psychophysiology; Biological and medical sciences; Bromodeoxyuridine - metabolism; Corticosterone - pharmacology; Cytarabine - administration & dosage; Cytarabine - pharmacology; Electrophysiology; Fundamental and applied biological sciences. Psychology; Hippocampus - cytology; Hippocampus - drug effects; Hippocampus - physiology; Injections, Intraventricular; Male; Neural Inhibition - drug effects; Neurogenesis - drug effects; Paroxetine - pharmacology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Sprague-Dawley; Reflex, Startle - drug effects; subventricular zone; Rat; Cytostatic; Rodentia; Central nervous system; prepulse inhibition disruption; Neurogenesis; Encephalon; Vertebrata; Mammalia; Animal; Intracerebral administration; sensorimotor gating; Gating; Hippocampus; Prepulse inhibition
• ISSN: 0959-4965; 1473-558X
• DOI: 10.1097/WNR.0b013e328324edcd

Adult neurogenesis in hippocampus is associated with behaviors such as learning. Hippocampus is involved in the regulation of prepulse inhibition (PPI), but the relationship between neurogenesis and PPI is unexplored. We conducted four experiments to determine the role of neural progenitor cell proliferation in PPI. Intracerebroventricular infusion of cytostatic cytosine arabinoside caused PPI disruption but repeated exposure to PPI sessions prevented the PPI disruption. Corticosterone treatment, which decreases hippocampal cell proliferation, caused PPI disruption, whereas antidepressant and exercise, which increased cell proliferation, did not affect PPI. These results suggest that cell proliferation is involved in the first encounter with PPI test while its importance may decrease upon repeated exposures to the tests.