Different protein turnover of interleukin‐6‐type cytokine signalling components

Interleukin (IL)‐6 and IL‐6‐type cytokines signal through the gp130/Jak/STAT signal transduction pathway. The key components involved are the signal transducing receptor subunit gp130, the Janus kinases Jak1, Jak2 and Tyk2, STAT1 and STAT3 of the family of signal transducers and activators of transc...

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Bibliographic Details
Published in:	European journal of biochemistry Vol. 265; no. 1; pp. 251 - 257
Main Authors:	Siewert, Elmar, Müller‐Esterl, Werner, Starr, Robin, Heinrich, Peter C., Schaper, Fred
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01-10-1999
Subjects:	Antigens, CD - metabolism Cytokine Receptor gp130 Cytokines - metabolism DNA-Binding Proteins - metabolism Half-Life Interleukin-6 - metabolism interleukin‐6 interleukin‐6‐type cytokines Intracellular Signaling Peptides and Proteins Membrane Glycoproteins - metabolism protein turnover Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatase, Non-Receptor Type 6 Protein Tyrosine Phosphatases - metabolism Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Recombinant Proteins - metabolism signal transduction Signal Transduction - physiology STAT1 Transcription Factor STAT2 Transcription Factor Trans-Activators - metabolism
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