Assessment of anti-HIV activity of some benzimidazolylthiazoles
Benzimidazolylthiazoles 2 were synthesized by condensing 1H-benzimidazole-2-acetonitrile (1) with sulphur and isothiocyanates. The syntheses of the Schiff bases 3, thioureas 4, and thiazolopyrimido[1,6-a]benzimidazoles 5 and 6 are also described. Seven compounds were evaluated in vitro against human...
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| Published in: | Archiv der Pharmazie (Weinheim) Vol. 325; no. 9; p. 565 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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Germany
1992
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| Abstract | Benzimidazolylthiazoles 2 were synthesized by condensing 1H-benzimidazole-2-acetonitrile (1) with sulphur and isothiocyanates. The syntheses of the Schiff bases 3, thioureas 4, and thiazolopyrimido[1,6-a]benzimidazoles 5 and 6 are also described. Seven compounds were evaluated in vitro against human HIV, however, no significant activity was observed with any of these compounds. |
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| AbstractList | Benzimidazolylthiazoles 2 were synthesized by condensing 1H-benzimidazole-2-acetonitrile (1) with sulphur and isothiocyanates. The syntheses of the Schiff bases 3, thioureas 4, and thiazolopyrimido[1,6-a]benzimidazoles 5 and 6 are also described. Seven compounds were evaluated in vitro against human HIV, however, no significant activity was observed with any of these compounds. |
| Author | Rida, S M Badawey, E A Hazzaa, A A Fahmy, H T |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/1444761$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_ejmech_2010_03_022 crossref_primary_10_1002_ardp_19953280406 crossref_primary_10_1007_BF02977463 crossref_primary_10_1080_17415990701397767 crossref_primary_10_4155_fmc_2018_0058 crossref_primary_10_1002_ardp_201000165 crossref_primary_10_1002_jhet_2414 crossref_primary_10_1080_17415990600600097 crossref_primary_10_1002_ardp_19973300304 crossref_primary_10_1080_00397910903161652 crossref_primary_10_1080_10426500903074858 crossref_primary_10_1002_jhet_293 |
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| SubjectTerms | Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Benzimidazoles - chemical synthesis Benzimidazoles - pharmacology HIV - drug effects Humans |
| Title | Assessment of anti-HIV activity of some benzimidazolylthiazoles |
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