Cardiac Size, Shape, and Ventricular Contractility in Fetuses at Sea Level With an Estimated Weight Less‐than 10th Centile

• Published in: Journal of ultrasound in medicine Vol. 41; no. 11; pp. 2703 - 2714
• Main Authors: Lee, Wesley, Mack, Lauren M., Miremadi, Roxanna, Furtun, Betul Yilmaz, Sangi‐Haghpeykar, Haleh, DeVore, Greggory R.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01-11-2022
• Subjects: fetal growth restriction; intrauterine growth restriction; speckle tracking; speckle tracking; fetal growth restriction; intrauterine growth restriction
• ISSN: 0278-4297; 1550-9613
• DOI: 10.1002/jum.15954

Objectives
To investigate cardiac size, shape, and ventricular contractility in fetuses with estimated fetal weight (EFW) <10th centile at sea level (Houston).
Methods
A prospective ultrasound study examined 37 fetuses with EFW <10th centile at sea level. High‐frequency cine clips were used to evaluate the 4‐chamber view including end‐diastolic measurements and global sphericity index. The size, shape, and contractility of both ventricles were analyzed with speckle tracking methods. Z scores were calculated using the mean ± standard deviation (SD) derived from normal controls. Measurements were abnormal if their Z score values were <−1.65 or >+1.65. The proportion of small fetuses with abnormal parameters was compared to normal reference ranges. Results were compared to a similar published study of small fetuses at higher altitude in Denver.
Results
About one‐third of Houston fetuses with EFW <10th centile had enlarged globular shaped 4‐chamber hearts with increased right ventricle (RV) area, RV basal‐apical length, RV base width, and left ventricle (LV) basal‐apical length measurements. Bilateral ventricular hypertrophy was often present. An increased proportion of Houston fetuses had increased ventricular contractility. However, decreased ventricular contractility was more prevalent for higher altitude fetuses.
Conclusions
Third trimester fetuses at sea level, with an EFW <10th centile, were often associated with enlarged and globular‐shaped hearts. They had increased global and longitudinal ventricular contractility as compared to controls. Higher altitude fetuses also had enlarged globular‐shaped hearts but with a greater proportion of cases having decreased ventricular contractility as compared to the sea level cohort.