The Influence of Attenuation and Scatter Corrections on Quantitative Analysis of 123I-FP-CIT SPECT Brain Imaging
Objective: [123I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) or dopamine transporter (DAT) SPECT scan quantitatively depicts striatum dopamine transporter density. The specific binding ratio (SBR) is important for Parkinson's disease (PD) diagnosis. Correc...
Saved in:
Published in: | Kita Kantō igaku (The Kitakanto Medical Journal) Vol. 69; no. 2; pp. 121 - 127 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
The Kitakanto Medical Society
01-05-2019
|
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Abstract | Objective: [123I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) or dopamine transporter (DAT) SPECT scan quantitatively depicts striatum dopamine transporter density. The specific binding ratio (SBR) is important for Parkinson's disease (PD) diagnosis. Correction techniques may improve 123I-FP-CIT image quality, but they are currently not standardized. We aim to determine attenuation correction (AC) and scatter correction (SC) influence on 123I-FP-CIT quantitative analysis.Methods: We preformed SPECT imaging on a striatal phantom representing striatum-to-background ratios ranging from 10:1 to 1:1. We used the Chang method for AC and triple energy window for SC. Commercially available software semi-automatically calculated SBR. We performed correlation analysis between SBR and the actual concentration ratio in four groups: no correction (NC), SC, AC, and combined correction (CC), paying particular attention to SBR values below the clinical cut-off (4.5). We applied the same imaging conditions, reconstruction, and corrections on 49 human 123I-FP-CIT SPECT studies. Asymmetric index values (AI) were also analyzed. Receiver operating characteristic (ROC) analysis provided AI diagnostic cut-off values in PD patients. PD patient population whose AI values were above these cut-off value were subject to a correlation study to confirm the association between their clinical symptoms and 123I-FP-CIT SPECT.Results: Phantom study. AC or CC increased SBR 123I-FP-CIT SPECT, making them very close to the standard ratios (AC: y=1.19x - 0.7; R2=0.98; CC: y=1.4x - 1.2; R2=0.98), while NC and SC underestimated SBR at lower values (1 to 4). Clinical study. There was no difference in SBR between NC and SC, while AC and CC produced significantly higher SBR than NC (p<0.0001). Only SC affected AI values (p<0.05). The association between clinical symptoms and 123I-FP-CIT imaging results were maintained only when either NC (n=12, p<0.05) or CC (n=14, p<0.05) was applied.Conclusions: AC increased SBR more than other corrections, while SC increased AI value more than other corrections. The association between clinical symptom and SPECT findings were maintained when either NC or CC was applied. These correction methods should be carefully selected for 123I-FP-CIT SPECT brain imaging. |
---|---|
AbstractList | Objective: [123I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) or dopamine transporter (DAT) SPECT scan quantitatively depicts striatum dopamine transporter density. The specific binding ratio (SBR) is important for Parkinson's disease (PD) diagnosis. Correction techniques may improve 123I-FP-CIT image quality, but they are currently not standardized. We aim to determine attenuation correction (AC) and scatter correction (SC) influence on 123I-FP-CIT quantitative analysis.Methods: We preformed SPECT imaging on a striatal phantom representing striatum-to-background ratios ranging from 10:1 to 1:1. We used the Chang method for AC and triple energy window for SC. Commercially available software semi-automatically calculated SBR. We performed correlation analysis between SBR and the actual concentration ratio in four groups: no correction (NC), SC, AC, and combined correction (CC), paying particular attention to SBR values below the clinical cut-off (4.5). We applied the same imaging conditions, reconstruction, and corrections on 49 human 123I-FP-CIT SPECT studies. Asymmetric index values (AI) were also analyzed. Receiver operating characteristic (ROC) analysis provided AI diagnostic cut-off values in PD patients. PD patient population whose AI values were above these cut-off value were subject to a correlation study to confirm the association between their clinical symptoms and 123I-FP-CIT SPECT.Results: Phantom study. AC or CC increased SBR 123I-FP-CIT SPECT, making them very close to the standard ratios (AC: y=1.19x - 0.7; R2=0.98; CC: y=1.4x - 1.2; R2=0.98), while NC and SC underestimated SBR at lower values (1 to 4). Clinical study. There was no difference in SBR between NC and SC, while AC and CC produced significantly higher SBR than NC (p<0.0001). Only SC affected AI values (p<0.05). The association between clinical symptoms and 123I-FP-CIT imaging results were maintained only when either NC (n=12, p<0.05) or CC (n=14, p<0.05) was applied.Conclusions: AC increased SBR more than other corrections, while SC increased AI value more than other corrections. The association between clinical symptom and SPECT findings were maintained when either NC or CC was applied. These correction methods should be carefully selected for 123I-FP-CIT SPECT brain imaging. [ABSTRACT] Objective: [123I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) or dopamine transporter (DAT) SPECT scan quantitatively depicts striatum dopamine transporter density. The specific binding ratio (SBR) is important for Parkinson's disease (PD) diagnosis. Correction techniques may improve 123I-FP-CIT image quality, but they are currently not standardized. We aim to determine attenuation correction (AC) and scatter correction (SC) influence on 123I-FP-CIT quantitative analysis. Methods: We preformed SPECT imaging on a striatal phantom representing striatum-to-background ratios ranging from 10:1 to 1:1. We used the Chang method for AC and triple energy window for SC. Commercially available software semi-automatically calculated SBR. We performed correlation analysis between SBR and the actual concentration ratio in four groups: no correction (NC), SC, AC, and combined correction (CC), paying particular attention to SBR values below the clinical cut-off (4.5). We applied the same imaging conditions, reconstruction, and corrections on 49 human 123I-FP-CIT SPECT studies. Asymmetric index values (AI) were also analyzed. Receiver operating characteristic (ROC) analysis provided AI diagnostic cut-off values in PD patients. PD patient population whose AI values were above these cut-off value were subject to a correlation study to confirm the association between their clinical symptoms and 123I-FP-CIT SPECT. Results: Phantom study. AC or CC increased SBR 123I-FP-CIT SPECT, making them very close to the standard ratios (AC: y=1.19x - 0.7; R2=0.98; CC: y=1.4x - 1.2; R2=0.98), while NC and SC underestimated SBR at lower values (1 to 4). Clinical study. There was no difference in SBR between NC and SC, while AC and CC produced significantly higher SBR than NC (p<0.0001). Only SC affected AI values (p<0.05). The association between clinical symptoms and 123I-FP-CIT imaging results were maintained only when either NC (n=12, p<0.05) or CC (n=14, p<0.05) was applied. Conclusions: AC increased SBR more than other corrections, while SC increased AI value more than other corrections. The association between clinical symptom and SPECT findings were maintained when either NC or CC was applied. These correction methods should be carefully selected for 123I-FP-CIT SPECT brain imaging. |
Author | Higuchi, Tetsuya Taketomi-Takahashi, Ayako Vy, Tran Vu Quynh Tsushima, Yoshito Nakajima, Takahito Suto, Takayuki Kanzaki, Takao Achmad, Arifudin Takahashi, Yasuyuki |
Author_xml | – sequence: 1 fullname: Kanzaki, Takao organization: Department of Radiology, Gunma University Hospital – sequence: 2 fullname: Vy, Tran Vu Quynh organization: Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine – sequence: 3 fullname: Higuchi, Tetsuya organization: Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine – sequence: 4 fullname: Nakajima, Takahito organization: Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine – sequence: 5 fullname: Achmad, Arifudin organization: Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine – sequence: 6 fullname: Takahashi, Yasuyuki organization: Department of Nuclear Medicine Technology, Hirosaki University Graduate School of Health Sciences – sequence: 7 fullname: Taketomi-Takahashi, Ayako organization: Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine – sequence: 8 fullname: Suto, Takayuki organization: Department of Radiology, Gunma University Hospital – sequence: 9 fullname: Tsushima, Yoshito organization: Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine |
BookMark | eNo9UMtOwzAQtBBIPC98gc9IKX6kjn3gUCIekZAAUc7W1t0Ut6mD7BSJv8dRgYvXGs_OeOaUHIY-ICGXnE2EqcrrzXY9UWbCBT8gJ1xrXnBu-GG-y1IWQgt1TE5TWjM2VUaWJ-Rz_oG0CW23w-CQ9i2dDQOGHQy-DxTCkr45yEikdR8juhFOND-97iAMfsi8L6SzAN138mnc50I2xf1LUTdz-vZyV8_pbQQfaLOFlQ-rc3LUQpfw4neekff7u3n9WDw9PzT17KlwJZ_mrzIoUaNUEqe8dcpwXWrJ2oVzSrSQs05Bg1TApHBQVcAcE3qhMuyw5At5Rq72ui72KUVs7Wf0W4jfljM7dmVzV1YZm7vK5Ic9eYtL76DrQ-cD2nW_izlZskuUm5x1YwXjxjKmDBPjsCxvj0clJROV0VnpZq-0TgOs8N8U4uBdh3-m4tf5H3cfEC0G-QOaz4os |
Cites_doi | 10.1016/S1474-4422(06)70549-X 10.1159/000445751 10.3389/fneur.2015.00146 10.1007/s00259-006-0155-x 10.2967/jnumed.111.100784 10.1111/ncn3.12082 10.1006/nimg.2001.0963 10.1371/journal.pone.0108328 10.1155/2011/195037 10.1002/mds.21479 10.1002/mds.25945 10.1002/mds.1265 10.1097/WNF.0b013e318211f945 |
ContentType | Journal Article |
Copyright | 2019, The Kitakanto Medical Society |
Copyright_xml | – notice: 2019, The Kitakanto Medical Society |
CorporateAuthor | Gunma University Graduate School of Medicine Gunma University Hospital Department of Diagnostic Radiology and Nuclear Medicine Department of Nuclear Medicine Technology Department of Radiology Hirosaki University Graduate School of Health Sciences |
CorporateAuthor_xml | – name: Gunma University Graduate School of Medicine – name: Hirosaki University Graduate School of Health Sciences – name: Department of Diagnostic Radiology and Nuclear Medicine – name: Department of Nuclear Medicine Technology – name: Department of Radiology – name: Gunma University Hospital |
DBID | AAYXX CITATION |
DOI | 10.2974/kmj.69.121 |
DatabaseName | CrossRef |
DatabaseTitle | CrossRef |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1881-1191 |
EndPage | 127 |
ExternalDocumentID | 10_2974_kmj_69_121 de3kitak_2019_006902_006_0121_01273302798 article_kmj_69_2_69_121_article_char_en |
GroupedDBID | .55 123 2WC ALMA_UNASSIGNED_HOLDINGS DIK E3Z JMI JSF KQ8 MOJWN OK1 P2P RJT W2D X7M AAYXX CITATION |
ID | FETCH-LOGICAL-c4153-20a4e8e363e51fc69184830fbcc62fa9745a8a36a032ca77a0c028b645ace41b3 |
ISSN | 1343-2826 |
IngestDate | Fri Aug 23 01:37:11 EDT 2024 Fri Nov 08 06:51:06 EST 2024 Wed Apr 05 14:13:41 EDT 2023 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c4153-20a4e8e363e51fc69184830fbcc62fa9745a8a36a032ca77a0c028b645ace41b3 |
OpenAccessLink | https://www.jstage.jst.go.jp/article/kmj/69/2/69_121/_article/-char/en |
PageCount | 7 |
ParticipantIDs | crossref_primary_10_2974_kmj_69_121 medicalonline_journals_de3kitak_2019_006902_006_0121_01273302798 jstage_primary_article_kmj_69_2_69_121_article_char_en |
PublicationCentury | 2000 |
PublicationDate | 2019-05-01 |
PublicationDateYYYYMMDD | 2019-05-01 |
PublicationDate_xml | – month: 05 year: 2019 text: 2019-05-01 day: 01 |
PublicationDecade | 2010 |
PublicationTitle | Kita Kantō igaku (The Kitakanto Medical Journal) |
PublicationTitleAlternate | Kitakanto Med J |
PublicationYear | 2019 |
Publisher | The Kitakanto Medical Society |
Publisher_xml | – name: The Kitakanto Medical Society |
References | 8. Vines DC, Ichise M, Liow J, et al. Evaluation of 2 scatter correction methods using a striatal phantom for quantitative brain SPECT. J Nucl Med Technol 2003; 31: 157-160. 19. Djaldetti R, Ziv I, Melamed E. The mystery of motor asymmetry in Parkinson's disease. Lancet Neurol 2006; 5: 796-802. 14. Pirker W, Djamshidian S, Asenbaum S, et al. Progression of dopaminergic degeneration in Parkinson's disease and atypical parkinsonism: A longitudinal beta-CIT SPECT Study. Mov Disord 2002; 17: 45-53. 12. Zijlmans J, Evans A, Fontes F, et al. [123I] FP-CIT spect study in vascular parkinsonism and Parkinson's disease. Mov Disord 2007; 22: 1278-1285. 16. Winz OH, Hellwig S, Mix M, et al. Image quality and data quantification in dopamine transporter SPECT: Advantage of 3-dimensional OSEM reconstruction? Clin Nucl Med 2012; 37: 866-871. 4. Djang DS, Janssen MJ, Bohnen N, et al. SNM practice guideline for dopamine transporter imaging with 123I-ioflupane SPECT 1.0. J Nucl Med 2012; 53: 154-163. 15. Jong BMD, Boer JAD. Iterative vs FBP for statistical parametric mapping of PET activation measurements: a compatative case study. NeuroImage 2002; 15: 175-181. 18. Koh J, Yamamoto K, Sakata M, et al. Quantitative reference value of dopamine transporter single-photon emission computed tomography in healthy Japanese older adults. Neurol Clin Neurosci 2016; 4: 215-219. 6. Tatsch K, Schwarz J, Mozley P, et al. Relationship between clinical features of Parkinson's disease and presynaptic dopamine transporter binding assessed with [123I]IPT and single-photon emission tomography. Eur J Nucl Med 1997; 24: 415-421. 21. Bieńkiewicz M, Górska-Chrza̧stek M, Siennicki J, et al. Impact of CT based attenuation correction on quantitative assessment of DaTSCAN (123I-Ioflupane) imaging in diagnosis of extrapyramidal diseases. Nucl Med Rev 2008; 11: 53-58. 13. Tossici-Bolt L, Hoffmann SMA, Kemp PM, et al. Quantification of [123I]FP-CIT SPECT brain images: an accurate technique for measurement of the specific binding ratio. Eur J Nucl Med Mol Imaging 2006; 33: 1491-1499. 7. Kim KM, Varrone A, Watabe H, et al. Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities. J Nucl Med 2003; 44: 512-519. 5. Habraken JB, Booij J, Slomka P, et al. Quantification and visualization of defects of the functional dopaminergic system using an automatic algorithm. J Nucl Med 1999; 40: 1091-1097. 9. Rajeevan N, Zubal IG, Ramsby SQ, et al. Significance of nonuniform attenuation correction in quantitative brain SPECT imaging. J Nucl Med 1998; 39: 1719-1726. 11. Warwick JM, Rubow S, du Toit M, et al. The role of CT-based attenuation correction and collimator blurring correction in striatal SPECT quantification. Int J Mol Imaging 2011; 2011: 195037. 17. Maebatake A, Imamura A, Kodera Y, et al. Evaluation of brain dopamine transporter SPECT images using iterative reconstruction and attenuation correction. J Nud Med 2015; 56 (Suppl.) : 2514. 20. Contrafatto D, Mostile G, Nicoletti A, et al. Single photon emission computed tomography striatal asymmetry index may predict dopaminergic responsiveness in Parkinson disease. Clin Neuropharmacol 2011; 34: 71-73. 3. de Celis Alonso B, Hidalgo-Tobón SS, Menéndez-González M, et al. Magnetic resonance techniques applied to the diagnosis and treatment of Parkinson's disease. Front Neurol 2015; 6: 146. 2. Pringsheim T, Jette N, Frolkis A, et al. The prevalence of Parkinson's disease: a systematic review and meta-analysis. Mov Disord 2014; 29: 1583-1590. 1. Hirsch L, Jette N, Frolkis A, et al. The incidence of Parkinson's disease: A systematic review and meta-analysis. Neuroepidemiology 2016; 46: 292-300. 10. Lange C, Seese A, Schwarzenböck S, et al. CT-based attenuation correction in I-123-ioflupane SPECT. PLoS ONE 2014; 9: e108328. 11 12 13 14 15 16 17 18 19 1 2 3 4 5 6 7 8 9 20 10 |
References_xml | – ident: 17 – ident: 19 doi: 10.1016/S1474-4422(06)70549-X – ident: 1 doi: 10.1159/000445751 – ident: 5 – ident: 3 doi: 10.3389/fneur.2015.00146 – ident: 13 doi: 10.1007/s00259-006-0155-x – ident: 4 doi: 10.2967/jnumed.111.100784 – ident: 18 doi: 10.1111/ncn3.12082 – ident: 15 doi: 10.1006/nimg.2001.0963 – ident: 10 doi: 10.1371/journal.pone.0108328 – ident: 11 doi: 10.1155/2011/195037 – ident: 16 – ident: 12 doi: 10.1002/mds.21479 – ident: 2 doi: 10.1002/mds.25945 – ident: 14 doi: 10.1002/mds.1265 – ident: 6 – ident: 9 – ident: 7 – ident: 8 – ident: 20 doi: 10.1097/WNF.0b013e318211f945 |
SSID | ssj0056934 ssib002484499 ssib002222924 ssib003104426 ssib029851801 ssib002219242 ssib028667290 ssib050977700 ssib001535672 ssib000961567 ssib023157378 ssib001509794 |
Score | 2.128394 |
Snippet | Objective: [123I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) or dopamine transporter (DAT) SPECT scan quantitatively... [ABSTRACT] Objective: [123I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) or dopamine transporter (DAT) SPECT scan... |
SourceID | crossref medicalonline jstage |
SourceType | Aggregation Database Publisher |
StartPage | 121 |
SubjectTerms | AI (asymmetric index) Attenuation correction; Scatter correction DAT scan SBR |
Title | The Influence of Attenuation and Scatter Corrections on Quantitative Analysis of 123I-FP-CIT SPECT Brain Imaging |
URI | https://www.jstage.jst.go.jp/article/kmj/69/2/69_121/_article/-char/en http://mol.medicalonline.jp/library/journal/download?GoodsID=de3kitak/2019/006902/006&name=0121-0127e |
Volume | 69 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
ispartofPNX | The Kitakanto Medical Journal, 2019/05/01, Vol.69(2), pp.121-127 |
link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3da9swEBdpN8agjH2y7AvB9hbc2ZatyG8bWUq8slKoV_YmZMXekhCnNMlD__veSbKjjD10g72YIMuyfPfz6c45_Y6QD0KXcahFFEyzugySOmVBGXIRIKk1EkLV2iSPTy6GZz_El3Ey7vXaQhe7tv-qaWgDXePO2b_QdjcoNMBv0DkcQetwvLPe87byiPEzN-AWW0Jvm6epDaUmWIJrY-1MIlyD2Z2N2XCGqUQ-VQksOnlwch6M8mJwcT4eFYAHNWsG-dIUOPK9W7z3KYyxwMrE3X9AX71po2kHb1TZYtkF9Fy17ZdG3bh2Di63MJ2bpvtSPZn9xJot5ny1WW9vurXkDEaYz5aqHe0XGCj_QwbunUr9Dxl_nqLLXfUsNEtYAHGi48-2bQLAhkx1vlm3FWAcfGPPRkd2S7Zb7iNLTfD7ShJDnAWqXiznxzw77i7ZY-Z2OpbQSfJMxniAnrJtx31zAMkDci8GK2ji_fzU841EYmJz6zakPLMpEO3zWS5dnMfH3Sz2vKf7cwggkBniaGmlZclVPP-oeEweOSXTz3ZWT0ivap6SB99c6sYzcgWSpx0w6aqmHjApAJM6YFIPmBRO-cCkLTDxeg-Y1ACTGmBSB8zn5PvJuBhNAlfuI9DgRcJDhyqpRMU4q9Ko1jyLRCJYWJda87hWIIhUCcW4Clms1XCoQg3OccmhWVdJVLIX5LBZNdVLQiFKT8HzD6tSQTwgpplxyjTjHBxqlao-ed-KUV5ZVhcJ0TAKu9UmCLtPuJVw1-eOGu-TT3sakc4-rOW0YgvEuMQXQBqa8Fia1FIcBtNAGCYSZOLVv977NXm4e7nekMPN9bZ6Sw7W0-07g79bQnbGNA |
link.rule.ids | 315,782,786,27933,27934 |
linkProvider | Flying Publisher |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Influence+of+Attenuation+and+Scatter+Corrections+on+Quantitative+Analysis+of+123I-FP-CIT+SPECT+Brain+Imaging&rft.jtitle=The+Kitakanto+Medical+Journal&rft.au=Kanzaki%2C+Takao&rft.au=Vy%2C+Tran+Vu+Quynh&rft.au=Higuchi%2C+Tetsuya&rft.au=Nakajima%2C+Takahito&rft.date=2019-05-01&rft.pub=The+Kitakanto+Medical+Society&rft.issn=1343-2826&rft.eissn=1881-1191&rft.volume=69&rft.issue=2&rft.spage=121&rft.epage=127&rft_id=info:doi/10.2974%2Fkmj.69.121&rft.externalDocID=article_kmj_69_2_69_121_article_char_en |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1343-2826&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1343-2826&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1343-2826&client=summon |