The synthesis of biologically active indolocarbazole natural products

• Published in: Natural product reports Vol. 38; no. 10; p. 1794
• Main Authors: Chambers, George E, Sayan, A Emre, Brown, Richard C D
• Format: Journal Article
• Language: English
• Published: England 20-10-2021
• Subjects: Biological Products - chemical synthesis; Biological Products - pharmacology; Carbazoles - chemical synthesis; Carbazoles - pharmacology; Humans; Indoles - chemical synthesis; Indoles - pharmacology; Structure-Activity Relationship
• ISSN: 1460-4752
• DOI: 10.1039/d0np00096e

Covering: up to 2020The indolocarbazoles, in particular indolo[2,3-
]pyrrolo[3,4-
]carbazole derivatives, are an important class of natural products that exhibit a wide range of biological activities. There has been a plethora of synthetic approaches to this family of natural products, leading to advances in chemical methodology, as well as affording access to molecular scaffolds central to protein kinase drug discovery programmes. In this review, we compile and summarise the synthetic approaches to the indolo[2,3-
]pyrrolo[3,4-
]carbazole derivatives, spanning the period from their isolation in 1980 up to 2020. The selected natural products include indolocarbazoles not functionalised at indolic nitrogen, pyranosylated indolocarbazoles, furanosylated indolocarbazoles and disaccharideindolocarbazoles.