Involvement of cholesterol efflux pathway in the control of cardiomyocytes cholesterol homeostasis

Abstract Although cholesterol-rich microdomains are highly involved in the functions of cardiomyocytes, the cholesterol homeostasis is largely unknown in these cells. We developed experimental procedures to assess cholesterol synthesis, cholesterol masses and cholesterol efflux from primary cultures...

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Bibliographic Details
Published in:	Journal of molecular and cellular cardiology Vol. 53; no. 2; pp. 196 - 205
Main Authors:	Reboulleau, Anne, Robert, Véronique, Vedie, Benoît, Doublet, Aline, Grynberg, Alain, Paul, Jean-Louis, Fournier, Natalie
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2012
Subjects:	Animals ATP Binding Cassette Transporter 1 ATP binding cassette transporter A1 ATP binding cassette transporter G1 ATP Binding Cassette Transporter, Sub-Family G, Member 1 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological Transport - drug effects Cardiomyocytes Cardiovascular Cells, Cultured Cholesterol - metabolism Cholesterol efflux Cholesterol homeostasis Cholesterol, LDL - metabolism Homeostasis - drug effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Pravastatin - pharmacology Rats Rats, Wistar Signal Transduction - drug effects Statin ABCA1 apo apolipoprotein CE ATP binding cassette transporter A1 Cardiomyocytes free cholesterol Statin liver X receptor/retinoid X receptor ATP binding cassette transporter G1 cholesteryl esters FC LXR/RXR ABCG1 Cholesterol homeostasis Cholesterol efflux
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