Generation of integration-free human induced pluripotent stem cells from a patient with sporadic Parkinson’s disease

A human induced pluripotent stem cell (iPSC) line (KKUi002-A) was generated from a skin fibroblast of a 57-years-old (at sampling) male patient diagnosed with a sporadic Parkinson’s disease (PD). A non-integration system was used to reprogram fibroblasts into iPSCs by an episomal vector (OCT4/p53, S...

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Bibliographic Details
Published in:	Stem cell research Vol. 77; p. 103416
Main Authors:	Lee, Yukyeong, Jeong, Dahee, Ham, Seokbeom, Son, Jaeseung, Ko, Kinarm
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 01-06-2024 Elsevier
Online Access:	Get full text
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Summary:	A human induced pluripotent stem cell (iPSC) line (KKUi002-A) was generated from a skin fibroblast of a 57-years-old (at sampling) male patient diagnosed with a sporadic Parkinson’s disease (PD). A non-integration system was used to reprogram fibroblasts into iPSCs by an episomal vector (OCT4/p53, SOX2/KLF4, L-MYC/LIN28). The KKUi002-A iPSCs displayed typical iPSC morphology, expressed pluripotency markers, differentiated into derivatives of three germ layers, and had a normal karyotype. These PD-derived iPSCs can be used to understand the mechanism underlying PD pathogenesis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1873-5061 1876-7753 1876-7753
DOI:	10.1016/j.scr.2024.103416