Minispectrometer with handheld probe for 5-ALA based fluorescence-guided surgery of brain tumors: preliminary study for clinical applications

• Published in: Photodiagnosis and photodynamic therapy Vol. 17; pp. 147 - 153
• Main Authors: Cornelius, J.F, Placke, J.M, Knipps, J, Fischer, I, Kamp, M, Steiger, H.J
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-03-2017
• Subjects: 5-ALA; Brain Neoplasms - pathology; Brain Neoplasms - surgery; Fluorescence-guided; Glioblastoma; Glioblastoma - pathology; Glioblastoma - surgery; Hematology, Oncology and Palliative Medicine; Humans; Internal Medicine; Meningioma; Meningioma - pathology; Meningioma - surgery; Metabolic imaging; Neurosurgical Procedures - instrumentation; Photosensitizing Agents - pharmacokinetics; Protoporphyrins - pharmacokinetics; Spectrometer; Spectrometry, Fluorescence - instrumentation; meningioma; glioblastoma; metabolic imaging spectrometer; 5-ALA; fluorescence-guided; Metabolic imaging; Fluorescence-guided; Spectrometer; Meningioma; Glioblastoma
• ISSN: 1572-1000; 1873-1597
• DOI: 10.1016/j.pdpdt.2016.12.007

Highlights • a handheld spectrometer was evaluated for 5-ALA fluorescence-guided brain tumor surgery. • the tool discriminated fluorescence intensity of glioblastomas (4.5 times higher) from meningiomas. • a no-touch mode of measurement was possible. • it determined PPIX tumor tissue concentration as good as a laboratory spectrometer. • the handheld spectrometer may become useful in deep surgical fields (e.g. parasellar, cavernous sinus)